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Pharmaceutical composition for treating drug-resistant tuberculosis

A composition and technology for tuberculosis, applied in the direction of antibacterial drugs, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of limited types and quantities of anti-tuberculosis drugs, ineffectiveness, and poor therapeutic effect, so as to improve immune regulation ability and strengthen treatment effect, the effect of reducing the dose

Active Publication Date: 2013-10-23
四川绵阳四〇四医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the limited types and quantities of existing anti-tuberculosis drugs, and to provide a drug-resistant tuberculosis drug-resistant tuberculosis treatment effect is poor, or even ineffective.

Method used

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  • Pharmaceutical composition for treating drug-resistant tuberculosis
  • Pharmaceutical composition for treating drug-resistant tuberculosis
  • Pharmaceutical composition for treating drug-resistant tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 The pharmaceutical composition of artemisinin and isoniazid

[0039] Pharmaceutical composition: 1 part of isoniazid, 50 parts of artemisinin.

Embodiment 2

[0040] Example 2 The pharmaceutical composition of dihydroartemisinin and rifampicin

[0041] Pharmaceutical composition: 1 part of rifampicin, 25 parts of dihydroartemisinin.

Embodiment 3

[0042] Example 3 The pharmaceutical composition of nano-chitosan dihydroartemisinin, rifampicin, ethambutol

[0043] Pharmaceutical composition: 1 part of rifampicin, 2 parts of ethambutol, 20 parts of nano dihydroartemisinin.

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Abstract

The invention relates to an artemisinin pharmaceutical composition, and particularly relates to a composition of nano chitosan artemisinin and antituberculosis drugs, used for treating drug-resistant tuberculosis. The pharmaceutical composition comprises the following effective components: the antituberculosis drugs, the nano chitosan artemisinin, three nano chitosan artemisinin derivatives or artemisinin and a derivative of artemisinin, wherein the nano chitosan artemisinin is prepared from the following ingredients by weight percent: 40-805 of artemisinin or artemisinin derivatives, 1-5% of polyvinyl pyrrolidone and 15-50% of nano chitosan. Artemisinin drugs, the nano chitosan artemisinin and derivatives, and the antituberculosis drugs are used as the pharmaceutical composition, so that drug-resistant tubercle bacillus can be inhibited and killed; and the pharmaceutical composition has a prominent curative effect on the drug-resistant tuberculosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating drug-resistant tuberculosis, in particular to a composition of artemisinin drugs and nano artemisinin and anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis has gradually increased and has become a major global public health problem. The increase in the infection rate of drug-resistant tuberculosis is an important factor causing the sharp rise of tuberculosis, and it also has a serious impact on the control of tuberculosis. According to the World Health Organization (WHO), about 2 billion people worldwide are infected with Mycobacterium tuberculosis. Although new cases of tuberculosis have declined between 2010 and 2011, tuberculosis is still a major cause of death from infectious diseases. Despite the large-scale use of BCG vaccination and anti-tuberculosis drugs, the infection rate of tuberculosis is still high, and the increase of dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/357A61K47/36A61K31/4409A61K31/496A61K31/4965A61P31/06A61K31/133
Inventor 曾娅莉王利民蒋涛王继相邓建军任雪松
Owner 四川绵阳四〇四医院
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