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Application of Aleuritopteris argentea Fee extract in preparation of drugs treating AIDS

A technology of Tongjingcao and extract, applied in the field of biomedicine, can solve the problems such as no reports on the AIDS drug of Tongjingcao or Tongjingcao extract.

Inactive Publication Date: 2014-02-19
孙成永 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above-mentioned documents and patents, etc., have not yet seen the report of Tongjingcao or Tongjingcao extract being used to prepare drugs for the treatment of AIDS

Method used

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  • Application of Aleuritopteris argentea Fee extract in preparation of drugs treating AIDS
  • Application of Aleuritopteris argentea Fee extract in preparation of drugs treating AIDS

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Tongjingcao Extract and Monomer Compounds

[0027] (1) 10kg of Herba Trichonia, using 40% ethanol as a solvent, extracted at 90°C, extracted twice, each extraction time was 2 hours, and the amount of solvent used each time was 12 times the weight of Herba Trichonia; filtered and combined extract, recover ethanol, concentrate, and dry to obtain Tongjingcao extract A;

[0028] (2) Add 15 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain the medicinal solution A. The medicinal solution A passes through the HPD600 macroporous adsorption resin column, elutes with water, and then uses a concentration of 60 % ethanol solution for elution, collect the 60% ethanol eluate, recover the ethanol, concentrate and dry, and then obtain the Herba Tongjingcao extract.

[0029]Take an appropriate amount of Herba Trichonia extract, and then go through 200-300 mesh silica gel column chromatography, elution w...

Embodiment 2

[0030] Example 2: Preparation of Tongjingcao Extract and Monomer Compounds

[0031] (1) 5 kg of Herbs, extract with water at 95°C, the number of extractions is 3 times, each extraction time is 1 hour, and the amount of solvent used for each time is 6 times the weight of Herbs; filter and combine the extracts , concentrated, dried, Detongjingcao Extract A;

[0032] (2) Add 10 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain the medicinal solution A. The medicinal solution A passes through a macroporous adsorption resin column, elutes with water, and then uses a concentration of 50% The ethanol solution was used for elution, and the 50% concentration ethanol eluate was collected, concentrated and dried, and the extract of Tongjingcao was obtained.

[0033] Take an appropriate amount of Herba Trichonia extract, and then go through 200-300 mesh silica gel column chromatography, elution with chloroform-methanol gradient (10...

Embodiment 3

[0034] Example 3: Preparation of Tongjingcao Extract and Monomer Compounds

[0035] (1) 5 kg of Herba Tinsis, using 50% ethanol as a solvent, extracting at 70°C, the number of extractions is 1 time, each extraction time is 4 hours, and the amount of solvent used for each time is 15 times the weight of Herbs; filter , combine the extracts, recover ethanol, concentrate, and dry to obtain Tongjingcao extract A;

[0036] (2) Add 20 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain the medicinal solution A. The medicinal solution A passes through a macroporous adsorption resin column, elutes with water, and then uses a concentration of 70% The ethanol solution was used for elution, and the 70% concentration ethanol eluate was collected, concentrated and dried, and the extract of Tongjingcao was obtained.

[0037] Take an appropriate amount of Herba Trichonia extract, and then go through 200-300 mesh silica gel column chromat...

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Abstract

The invention relates to new application of an Aleuritopteris argentea Fee extract in preparation of drugs treating AIDS. The Aleuritopteris argentea Fee extract is prepared by: taking Aleuritopteris argentea Fee as the raw material, conducting extraction with 50%-90% ethanol, and carrying out macroporous adsorption resin and other chromatography purification. The Aleuritopteris argentea Fee extract provided by the invention is of great significance in preparation of drugs treating AIDS.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of an extract of a Chinese medicinal material in the preparation of a drug for treating AIDS, in particular to the application of the extract of Tongjingcao in the preparation of a drug for the treatment of AIDS. Background technique [0002] AIDS, Acquired Immune Deficiency Syndrome, English name Acquired Immune Deficiency Syndrome, AIDS. It is a syndrome in which human immunodeficiency caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV) is complicated by a series of opportunistic infections and tumors, and severe cases can lead to death. At present, AIDS has become a public health problem that seriously threatens the health of people all over the world. HIV was first discovered in humans in 1983. Currently, AIDS has changed from a fatal disease to a manageable chronic disease. HIV belongs to the human lentivirus group in the genus Lentivirus of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P31/18
Inventor 孔倩倩
Owner 孙成永
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