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Flucloxacillin sodium and amoxicillin sodium composition for injection

A technology of amoxicillin sodium and flucloxacillin sodium, applied in the directions of inorganic non-active ingredients, heterocyclic compound active ingredients, antibacterial drugs, etc., can solve the problem of poor stability, affecting clinical efficacy, and active ingredient flucloxacillin sodium protection question

Active Publication Date: 2015-01-21
北京元延医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method simply mixes and subpackages the two, and does not protect the active ingredients amoxicillin sodium and flucloxacillin sodium accordingly, resulting in poor stability of the product for long-term storage and seriously affecting the clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0092] Preparation Example 1: Preparation of a composition in the form of sterile powder for injection

[0093] formula:

[0094] Flucloxacillin sodium (weight is based on flucloxacillin): 1 part by weight,

[0095] Amoxicillin sodium (weight is based on amoxicillin): 1 part by weight,

[0096] Sodium chloride: 0.1 parts by weight.

[0097] Preparation method: All materials are aseptically treated aseptic materials and meet the requirements of pharmaceutical raw materials. Each material was aseptically passed through an 80-mesh sieve for later use. The used vials, rubber stoppers and other utensils were washed and sterilized. The entire preparation process was carried out in a sterile room according to the operating procedures of the sterile room. Weigh flucloxacillin sodium, amoxicillin sodium, and sodium chloride according to the prescribed amount; first mix flucloxacillin sodium and sodium chloride in a sterile mixer for at least 30 minutes until uniform, then mix th...

preparation example 2

[0098] Preparation Example 2: Preparation of a composition in the form of sterile powder for injection

[0099] formula:

[0100] Flucloxacillin sodium (weight is based on flucloxacillin): 1 part by weight,

[0101] Amoxicillin sodium (weight is based on amoxicillin): 0.5 parts by weight,

[0102] Sodium chloride: 0.15 parts by weight.

[0103] Preparation method: carry out with reference to the method of Preparation Example 1.

preparation example 3

[0104] Preparation Example 3: Preparation of a composition in the form of sterile powder for injection

[0105] formula:

[0106] Flucloxacillin sodium (weight is based on flucloxacillin): 1 part by weight,

[0107] Amoxicillin sodium (weight is based on amoxicillin): 1.5 parts by weight,

[0108] Sodium chloride: 0.05 parts by weight.

[0109] Preparation method: carry out with reference to the method of Preparation Example 1.

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PUM

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Abstract

The invention relates to a flucloxacillin sodium and amoxicillin sodium composition for injection, and in particular relates to a medicament composition. The medicament composition comprises flucloxacillin sodium and amoxicillin sodium. In the medicament composition, the flucloxacillin sodium adopts flucloxacillin and the amoxicillin sodium adopts amoxicillin, wherein the weight ratio of flucloxacillin to amoxicillin is 1:(0.5-1.5). The composition provided by the invention has excellent properties.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound antibiotic, in particular to a compound antibiotic drug composed of flucloxacillin sodium and amoxicillin sodium. The present invention also relates to the pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium powder injection and its preparation method, and further relates to its new application in the preparation of medicines for treating infections such as pelvic infection. Background technique [0002] Each bottle of commercially available flucloxacillin sodium and amoxicillin sodium contains flucloxacillin sodium and amoxicillin sodium, respectively, the ratio of the marked amounts of flucloxacillin and amoxicillin is usually 1:1, and usually each bottle contains flucloxacillin and amoxicillin Amoxicillin is 250mg or 500mg respectively, and it should be diluted with 0.9% sodium chloride injection for intravenous injection and used up within 4 h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/431A61K47/02A61P31/04A61K31/43
Inventor 王立强
Owner 北京元延医药科技股份有限公司
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