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Application of immobilized carboxyester hydrolase in side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin

A technology for flucloxacillin, oxacillin, and carboxyl ester hydrolase, which is applied in the directions of immobilized enzymes, hydrolase, enzymes, etc., can solve the problems of high cost, low yield and high energy consumption, and achieves low cost and economical efficiency. Significant benefits and high yields

Pending Publication Date: 2020-02-11
河北慧林生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin generally uses strong alkali (KOH, NAOH) hydrolysis, and the traditional method has several disadvantages. High; 2. The yield is not high, the highest not exceeding 85%; 3. The cost is relatively high

Method used

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  • Application of immobilized carboxyester hydrolase in side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin
  • Application of immobilized carboxyester hydrolase in side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin
  • Application of immobilized carboxyester hydrolase in side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin

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Embodiment 1

[0018] The application of a kind of immobilized carboxyl ester hydrolase provided in the embodiment of the present invention in the synthesis of cloxacillin side chain, its chemical reaction formula is respectively:

[0019] .

Embodiment 2

[0021] The application of a kind of immobilized carboxyl ester hydrolase provided in the embodiment of the present invention in dicloxacillin side chain synthesis, its chemical reaction formula is respectively:

[0022] .

Embodiment 3

[0024] The application of a kind of immobilized carboxyl ester hydrolase in the synthesis of flucloxacillin side chain that the embodiment of the present invention provides, its chemical reaction formula is respectively:

[0025] .

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Abstract

The invention belongs to the technical field of antibiotic production, and particularly relates to application of immobilized carboxyester hydrolase in side chain synthesis of cloxacillin, diclocillin, flucloxacillin and oxacillin. Compared with a traditional hydrolysis method of strong bases (KOH, NAOH), the application has the following advantages: firstly, the hydrolysis condition is mild, andis generally room temperature; secondly, the yield is very high and can reach more than 98%; thirdly, the cost is relatively low, and the economic benefit is remarkable; fourthly, due to high yield, the quantity of byproducts and sewage is extremely small; and fifthly, the immobilized carboxyester hydrolase can be reused.

Description

technical field [0001] The invention belongs to the technical field of antibiotic production, and particularly relates to the application of an immobilized carboxyl ester hydrolase in the synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin side chains. Background technique [0002] The traditional side chain synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin generally uses strong alkali (KOH, NAOH) hydrolysis, and the traditional method has several disadvantages. Higher; 2. The yield is not high, the highest not exceeding 85%; 3. The cost is relatively high. Contents of the invention [0003] The invention provides an application of an immobilized carboxyl ester hydrolase in the synthesis of cloxacillin, dicloxacillin, flucloxacillin and oxacillin side chains, which can solve the problems pointed out in the background technology. [0004] A kind of application of immobilized carboxyl ester hydrolase in cloxacillin, dicloxacillin, flucl...

Claims

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Application Information

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IPC IPC(8): C12P17/14C12N9/18C12N11/00
CPCC12P17/14C12N9/18C12N11/00
Inventor 陈涛
Owner 河北慧林生物科技有限公司