Dipeptide QE with dual functions of lowering blood pressure and lowering blood fat and application thereof
A lipid-lowering, dual-function technology applied in the field of active dipeptides
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Embodiment 1
[0058] 1) ACE inhibitory activity of dipeptide QE at a concentration of 1.0 mg / mL:
[0059] Chromatographic conditions: Solvent I is 0.05% trifluoroacetic acid (TFA) and 0.05% triethylamine (TTA) dissolved in deionized water (that is, every liter of solvent I contains 0.5mL of trifluoroacetic acid and 0.5mL of triethylamine ), solvent II is 100% chromatographically pure acetonitrile. The ratio of solvent Ⅰ to solvent Ⅱ is 70%: 30% (volume ratio), ultimate3000 Diane liquid chromatograph, and the chromatographic column is watersSymmetry C 18 5μm4.6×250mm, the flow rate is 0.5mL / min, the injection volume is 10μL, the detection wavelength is 225nm, and the detection column temperature is 30°C.
[0060] Detection method: The dipeptide QE obtained by chemical synthesis is tested for activity (the detection method is the same as above). At this point the QE concentration was 1.0 mg / mL.
[0061] Results: The ACE inhibitory activity of dipeptide QE at 1.0 mg / mL was 89.18%.
[0062]...
Embodiment 2
[0067] 1) ACE inhibitory activity of dipeptide QE at a concentration of 2.0 mg / mL:
[0068] Chromatographic conditions: solvent Ⅰ is 0.05% trifluoroacetic acid (TFA) and 0.05% triethylamine (TTA) dissolved in deionized water; solvent Ⅱ is 100% chromatographically pure acetonitrile. The ratio of solvent Ⅰ to solvent Ⅱ is 70%: 30%, the ultimate3000 Diane liquid chromatograph, the chromatographic column is waters Symmetry C 18 5μm4.6×250mm, the flow rate is 0.5mL / min, the injection volume is 10μL, the detection wavelength is 225nm, and the detection column temperature is 30°C.
[0069] Detection method: The dipeptide QE obtained by chemical synthesis is tested for activity (the detection method is the same as above). At this point the QE concentration was 2.0 mg / mL.
[0070] Results: The ACE inhibitory activity of dipeptide QE at 2.0 mg / mL was 96.11%.
[0071] 2) HMG-CoA reductase inhibitory activity of dipeptide QE at a concentration of 2.0 mg / mL:
[0072] Chromatographic co...
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