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Application of eryngiolide A in the treatment of acute gout

A technology for acute gout and medicines, applied in the field of application of Eryngiolide A in the preparation of medicines for the treatment of acute gout, which can solve problems such as aplastic anemia and neutropenia, and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics

Active Publication Date: 2015-08-05
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

Method used

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  • Application of eryngiolide A in the treatment of acute gout
  • Application of eryngiolide A in the treatment of acute gout
  • Application of eryngiolide A in the treatment of acute gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Preparation of the compound Eryngiolide A tablet involved in the present invention:

[0017] Take 20 grams of compound Eryngiolide A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0018] Embodiment 2: the preparation of the compound Eryngiolide A capsule of the present invention:

[0019] Get 20 grams of compound Eryngiolide A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

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Abstract

The invention provides a new application of Eryngiolide A in medicine, in particular to an application of Eryngiolide A in preparing a drug for treating acute gout. Experimental study results prove that Eryngiolide A has a protective effect on an acute gout model with human blood vessel endothelial cell damage caused by urate, and inhibits ICAM-1 (Intercellular Cell Adhesion Molecule-1) expression, so that Eryngiolide A can be used for preparing the drug for treating an acute gout inflammation. The application of Eryngiolide A in preparing the drug for treating the acute gout is disclosed for the first time; since a matrix type is brand-new, and Eryngiolide A has unexpectedly strong activity on preventing and treating the acute gout, no probability of inspiration given by other compounds exists; and Eryngiolide A has the characteristic of prominent substantiality, and obviously has a marked progress for preventing and treating the acute gout at the same time.

Description

technical field [0001] The present invention relates to the new application of Eryngiolide A in medicine, in particular to the application of Eryngiolide A in the preparation of medicines for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to precipitate and crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroida...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P19/06
Inventor 吴俊华黄蓉王忠夏龚霞冯怡
Owner NANJING UNIV
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