40results about How to "Strong control activity" patented technology

A tetrazolinone compound represented by formula (1):wherein Q represents a 6-membered aromatic heterocyclic group optionally having one or more atoms or groups selected from Group P1, provided that a heteroatom constituting the heterocyclic group is a nitrogen atom, and the number of nitrogen atom is 1, 2, or 3; R1, R2, R3, and R11 each represents a C1-C6 alkyl group optionally having one or more atoms or groups selected from Group P2; R4 and R5 each represents a hydrogen atom, etc.; R6 represents a C1-C6 alkyl group optionally having one or more halogen atoms, etc.; R7, R8, and R9 each represents a hydrogen atom, etc.; and X represents an oxygen atom or a sulfur atom, has excellent control activity against pests.

The invention relates to a composite germicide, which simultaneously comprises three components, namely azoxystrobin, difenoconazole and cyproconazole. The germicide is prepared from the following active ingredients in percentage by weight: 1 to 40 percent of azoxystrobin, 1 to 30 percent of difenoconazole, 1 to 40 percent of cyproconazole, a wetting agent, a dispersant, an emulsifying agent, a thickening agent, a stabilizer, an antifreezing agent, an antifoaming agent and a solid carrier or a solvent. The composite germicide has effects and use which are obviously superior to those of germicides comprising one or two components.

The invention provides a bactericidal composition, which comprises an active component A and an active component B, wherein the component A is prochloraz or an agriculturally acceptable salt compound thereof, and the component B is pyrimethanil. The weight ratio of the component A to the component B is between 0.05 and 50, preferably between 0.08 and 30. The invention also provides a preparation method and application of the composition. Test results show that the bactericidal composition has obvious synergy, more important, the application rate is greatly reduced, the use cost is reduced, andfor certain diseases generating resistance to a prochloraz single agent, the bactericidal composition still has high activity. The bactericidal composition can effectively control certain special fungal diseases of crops, such as food crops, economic crops, fruits, vegetables, flowers and the like. By compounding bactericides with different action mechanisms and action modes, the bactericidal composition effectively reduces the application rate of each single agent, and has good functions in the aspects of enlarging the bactericidal spectrum, delaying the fungal resistance, improving the control effect and the like.

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

The present invention relates to Bacillus methylotrophicus strain DR-08 which produces a natural volatile compound and has antimicrobial activity, and a use thereof. The Bacillus methylotrophicus strain DR-08 according to the present invention, which is an antagonistic microorganism for controlling phytopathogenic microorganisms, and secondary metabolites produced by the strain, which include antibacterially- and antifungally-active non-volatile and volatile materials, are harmless to humans and domestic animals, and exhibit excellent control activity against various phytopathogenic bacteria and fungi while not causing environmental pollution. Thus, the strain and the secondary metabolites can be very usefully used for controlling various plant diseases in an environmentally-friendly manner.

The invention relates to lung cancer preventing and treating composition extracted from selfheal and / or garden orache and application thereof in preparation of lung cancer preventing and treating medicine. The composition comprises phenolic acid component, flavone component and triterpene component and is characterized in that the weight ratio of the phenolic acid component, flavone component and triterpene component is 5-70: 2-60: 0.5-40. In optimum proposal, the phenolic acid component takes caffeic acid and rosmarinic acid as typical ingredients; the flavone component takes rutin and quercetin as typical ingredients; the triterpene component takes ursolic acid and oleanolic acid as typical ingredients; the weight ratio of the caffeic acid, rosmarinic acid, rutin, quercetin, ursolic acid and oleanolic acid is 0-20: 5-50: 2-40: 0-20: 0.25-20: 0.25-20. The invention overcomes the defect of control is difficult in the prior art, active component is separated, purified and enriched, process is simple; preventing and treating activity on lung cancer and related diseases is strong; and mass production can be carried out.

An aromatic compound represented by formula (1):wherein R1 and R2 each independently represents a halogen atom, a C1-C4 alkyl group, or a C1-C4 haloalkyl group; m and n each independently represents an integer of 0 to 4; R3 and R4 each represents a hydrogen atom; Y represents formula: —OC(═X)ZR5 or —SC(═X)ZR5; R5 represents a C1-C3 alkyl group optionally having one or more halogen atoms; Z represents a sulfur atom, NR8, or a direct bond; R8 represents a C1-C3 alkyl group or a hydrogen atom; Q represents a pyrazolyl group optionally having a substituent; and W and X each independently represents an oxygen atom or a sulfur atom, has excellent control activity against pests.

The invention belongs to the field of pesticides and relates to a bactericidal composition containing valifenalate. The bactericidal composition containing valifenalate comprises an active ingredientA and an active ingredient B at a ratio of parts by weight of 1:30-30:1, wherein the active ingredient A is valifenalate; and the active ingredient B is pyraclostrobin, dimethomorph, iprodione or propamocarb. The invention provides the bactericidal composition containing valifenalate and the application of the bactericidal composition. The bactericidal composition is efficient, low in toxicity andlong in lasting period, and can reduce generation of pesticide resistance of diseases, and a dose can be reduced.

The invention provides a new use of Aphanamixoid A in medical science, and particularly relates to application of preparation of the Aphanamixoid A in medicines curing acute gout. Experiment research indicates that the Aphanamixoid A has protective effect on an acute gout model in which urate causes damage of vascular endothelial cell, and restrains expression of intercellular cell adhesion molecule (ICAM)-1. Therefore, the Aphanamixoid A can be used for preparation of the medicines curing acute gout inflammation. Use of the Aphanamixoid A in preparation of the medicines curing the acute gout is made public for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and the Aphanamixoi A has an unexpectedly high activity of preventing and curing the acute gout, probability of other compounds giving any revelation for the Aphanamixoi A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in preventing and curing the acute gout.

The invention provides a new application of Orientin in medicine, specifically the application of Orientin in the preparation of medicine for treating acute gout. Experimental research results show that Orientin has a protective effect on the acute gout model of human vascular endothelial cell damage caused by urate, and inhibits the expression of ICAM‑1. Therefore, Orientin can be used to prepare a drug for treating acute gout inflammation. The use of Orientin involved in the present invention in the preparation of medicines for the treatment of acute gout is disclosed for the first time. Since the skeleton type belongs to a new skeleton type, and its preventive and treatment activity for acute gout is so strong that it is unexpected, there is no possibility of giving any inspiration from other compounds , has outstanding substantive features, and it is obviously a significant progress in the prevention and treatment of acute gout.

The invention provides a novel use of Aphanamgrandiol A in medical science, and in particular relates to an application of Aphanamgrandiol A in preparation of medicines for treating acute gout. Experimental research results show that the Aphanamgrandiol A has the protective effect on an acute gout model of urate-caused injury of human vascular endothelial cells and inhibits expression of ICAM-1 (Intercellular Adhesion Molecule 1), so that the Aphanamgrandiol A can be used to prepare medicines for treating acute gouty inflammation. The application of the Aphanamgrandiol A in preparation of medicines for treating acute gout provided by the invention is disclosed for the first time. As the framework type of the Aphanamgrandiol A is a novel framework type, and the activity of the Aphanamgrandiol A to prevent and treat acute gout is unexpectedly strong, the probability of giving any indication by other compounds does not exist. The Aphanamgrandiol A has remarkable substantive characteristics and meanwhile has a remarkable progress for preventing and treating acute gout.

The invention provides a new application of Sarcaboside A in medical science, and in particular provides application of Sarcaboside A in preparation of a drug for treating acute gout. The experimental result shows that Sarcaboside A has a protective effect on an acute gout model of urate-caused human vascular endothelial cell injuries and is capable of inhibiting the expression of ICAM (Intercellular Adhesion Molecule-1), and thus, Sarcaboside A can be used for preparing the drug for treating acute gout inflammation. The application of Sarcaboside A in preparation of the drug for treating the acute gout is disclosed by the invention for the first time. As the skeleton type is brand new and Sarcaboside A has unexpectedly strong activity in prevention and treatment of acute grout, the possibility that any enlightenments are given by other compounds does not exist. Sarcaboside A has prominent substantive features and has remarkable progress when being used for preventing and treating acute gout.

The present invention relates to a novel malononitrile compound represented by the formula (A): wherein, R1 represents C1 to C6 alkyl that may be substituted with halogen, C2 to C6 alkenyl that may be substituted with halogen, etc; R2 represents hydrogen atom or C1 to C6 alkyl that may be substituted with halogen; R3 represents hydrogen atom or C1 to C6 alkyl; R4 represents hydrogen atom or C1 to C6 alkyl; R5 represents C1 to C6 alkyl that may be substituted with halogen, C3 to C6 alkenyl that may be substituted with halogen, etc, or R4 and R5 may be combined at their terminal and represent ethylene that may be substituted with C1 to C3 alkyl or trimethylene that may be substituted with C1 to C3 alkyl; and Z1 and Z2, which are the same or different, represent oxygen atom or sulfur atom. The malononitrile compound has an efficient pesticidal activity and can control effectively pests such as insect pests, acarine pests, nematode pests and the like.

The present invention provides a new use of Myriberine A in medicine, specifically an application of the Myriberine A in preparation of an acute gout treatment drug. Experimental research results show that the Myriberine A provides a protection effect for an acute gout model with human vascular endothelial cell damage caused by urate, and can be provided for inhibiting ICAM-1 expression, such that the Myriberine A can be used for preparing the acute gout inflammation treatment drug. According to the present invention, the use of the Myriberine A in acute gout treatment drug preparation is firstly disclosed, the skeleton belongs to a completely-new skeleton type, acute gout prevention and treatment activity of the drug is strong, possibility that any revelation is provided by other compounds does not exist, the drug has prominent substantive characteristics, and significant progress is provided for acute gout prevention and treatment with the drug.

A tetrazolinone compound represented by formula (1):wherein R1 and R2 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R3 represents a C1-C3 alkyl group optionally having one or more halogen atoms; R4, R5, and R6 each represents a hydrogen atom or a halogen atom; R7 represents a C1-C3 alkyl group; Q represents a divalent group selected from Group P4; and A represents a C7-C18 aralkyloxy group optionally having one or more atoms or groups selected from Group P3, has excellent control activity against pests.

The invention relates to a pesticide composition and an application thereof. The effective components of the pesticide composition are chlorobenzene ester amide and prochloraz with the weight part ratio of 20:1-1:20. The complex formulation of the effective components provides obvious synergism, and has excellent control effect for various fungal diseases on the fruit and vegetable crops and grain crops. The pesticide composition increases the control effect to gray mold, has good treatment effect for diseases such as anthracnose and leaf spot, enlarges bacteriocidal spectrum, reduces pesticide application amount, reduces residual quantity of the pesticide on the crops, reduces the environment pollution, and delays the generation of disease resistance.

The invention relates to lung cancer preventing and treating composition extracted from selfheal and / or garden orache and application thereof in preparation of lung cancer preventing and treating medicine. The composition comprises phenolic acid component, flavone component and triterpene component and is characterized in that the weight ratio of the phenolic acid component, flavone component andtriterpene component is 5-70: 2-60: 0.5-40. In optimum proposal, the phenolic acid component takes caffeic acid and rosmarinic acid as typical ingredients; the flavone component takes rutin and quercetin as typical ingredients; the triterpene component takes ursolic acid and oleanolic acid as typical ingredients; the weight ratio of the caffeic acid, rosmarinic acid, rutin, quercetin, ursolic acid and oleanolic acid is 0-20: 5-50: 2-40: 0-20: 0.25-20: 0.25-20. The invention overcomes the defect of control is difficult in the prior art, active component is separated, purified and enriched, process is simple; preventing and treating activity on lung cancer and related diseases is strong; and mass production can be carried out.

Disclosed is a novel transition metal complex containing N-heterocyclic carbene and a sulfonamide group, or N-heterocyclic carbene and an amide group, and application thereof, the transition metal complex having a wider range of general purposes in olefin metathesis and being able to be variably controlled in reactivity.

The invention provides a novel use of Foveoeudesmenone in medical science and concretely relates to a use of Foveoeudesmenone in preparation of a drug for treating acute gout. An experiment research result shows that Foveoeudesmenone has protection effects on a urate-caused human vascular endothelium injury and can inhibit ICAM-1 expression and thus Foveoeudesmenone can be used for preparation of a drug for treating acute gout inflammation. The use of Foveoeudesmenone in preparation of a drug for treating acute gout is disclosed first. The skeleton type of the Foveoeudesmenone belongs a novel skeleton type, the Foveoeudesmenone has unexpected acute gout prevention and treatment activity, is free of any enlightenment provided by other compounds and has prominent substantive features, and the use of Foveoeudesmenone in prevention and treatment on acute gout has substantial progress.

The invention provides new application of Gypensapogenin A in the medicine, and in particular relates to application of Gypensapogenin A in preparing a medicine for treating acute gout. Experiment research results indicates that Gypensapogenin A has the protective effect on acute gout models with human blood vessel endothelium cells damage cuased by urate, and restrains ICAM (intercellular adhesion molecule)-1 expression, so that Gypensapogenin A can be used for preparing the medicine for treating acute gout inflammation. The application of Gypensapogenin A in preparing the medicine for treating acute gout, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the acute gout preventing activity of Gypensapogenin A isextremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin A has outstanding actual characteristics. Meanwhile, Gypensapogenin A has outstanding progress when being used for preventing and treating acute gout.

The invention provides a new application of Chukrasone B in medical science, and particularly relates to an application of the Chukrasone B in the preparation of medicines for treating acute gout. Experimental research results show that the Chukrasone B has a protection effect on the human vascular endothelial cell damaged acute grout caused by monosodium urate and can be used for inhibiting the expression of ICAM-1 (Intercellular Cell Adhesion Molecule-1), therefore, the Chukrasone B can be used for the preparation of the medicines for treating acute gout inflammation. The application of the Chukrasone B in the preparation of the medicines for treating the acute gout is disclosed by the invention for the first time. As the skeleton type of the Chukrasone B belongs to a bran-new skeleton type and the Chukrasone B has unexpected strong activity on the prevention and treatment of the rheumatoid rhinitis, the possibility that other compounds provide revelation does not exist. The Chukrasone B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for preventing and treating the acute gout.

The invention discloses 2-pyridine-oxyl(sulfide) benzoyloxy enoates compound with general formula(I, II); wherein X is H or S; R1 is H, halogen, or 4,6- dimethoxy pyrimidine-2- radicel or one of the following groups; methyls on N-O bonds and double bonds are in maleinoid form or anti form; R2,R3,R4,R6,R7 are selected from H or alkyl from C1-C6; R5 is alkyl from C1-C6, alcoxyl-alkyl from C2-C6, alkenyl from C3-C6 or alkynyl from C3-C6; radicals of R6 and R7 are in maleinoid form or anti form; R8 is alkyl from C1-C6, alkenyl from C3-C6 or alkynyl from C3-C6. The compound (I, II)is of activity in weeding and is safe to crops like soybean, cotton, earthnut, cole, corn, etc.

The invention provides a herbicide composition consisting of 2-[(4,6-dimethoxypyrimidin-2-yl)hydroxy-methyl]-6-methoxymethyl-N-difluoromethanesulfonylanilide as the component (A) and any compound selected from more than 20 kinds of specific compounds such as orbencarb and the like as the component (B), heretofore not combined with the component (A) compound. Dispensation of the herbicide composition to paddy fields, lawns, dry fields, or non-agricultural lands gives excellent weed-controlling effects on a variety of weeds and causes no or little phytotoxicities on valuable cultivated plants.

The invention discloses an aryloxy phenoxy propionate compound as well as a preparation method and application thereof, the aryloxy phenoxy propionate compound is shown in the specification, and in the formula, R1 is methyl, ethyl or isopropyl; r2 is fluorine, chlorine, difluoromethyl or trifluoromethyl. The aryloxy phenoxy propionate compound provided by the invention has excellent prevention and control activity on weeds, can be used as an active ingredient of a herbicide, can prevent and remove grassy weeds such as barnyard grass and moleplant seeds in a paddy field, and is safe to paddy rice.

The invention provided new applications of Chukrasone A in medical science, and more specifically provides applications of Chukrasone A in preparation of medicines used for treating acute gout. Experiment research indicates that Chukrasone A has protective effect on an acute gout models with human blood vessel endothelium cell damages caused by urate, and is capable of restraining expression of ICAM-1. Therefore, Chukrasone A can be used for preparation of medicines to treat acute gout inflammation. Applications of Chukrasone A in preparation of medicines used for treating acute gout are disclosed for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and Chukrasone A has an unexpectedly high activity of preventing and curing acute gout, probability of other compounds giving any revelation for Chukrasone A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in preventing and curing acute gout.

The invention relates to a pesticide composition containing bromopol and prothioconazole and an application of the pesticide composition. The pesticide composition contains active components includingbromopol and prothioconazole, and the ratio of bromopol to prothioconazole in parts by weight is 10:1 to 1:10. The composition can be prepared into agriculturally acceptable dosage forms such as missible oil, a suspension agent, water dispersible granules, wettable powder and Emulsion in Water. The active components of the composition disclosed by the invention are reasonably matched, the activity and the bactericidal effect are not calculated by simply superposing the activity of each component, the compound synergistic effect is remarkable, and the dosage of effective components of a compound agent is obviously reduced as compared with that of a single agent. The pesticide composition containing bromopol and prothioconazole is suitable for preventing and controlling diseases caused by bacteria and particularly preventing and controlling citrus canker, cruciferae soft rot and rice bacterial leaf blight.

The invention relates to a pesticide composition and an application thereof. The effective components of the pesticide composition are chlorobenzene ester amide and prochloraz with the weight part ratio of 20:1-1:20. The complex formulation of the effective components provides obvious synergism, and has excellent control effect for various fungal diseases on the fruit and vegetable crops and grain crops. The pesticide composition increases the control effect to gray mold, has good treatment effect for diseases such as anthracnose and leaf spot, enlarges bacteriocidal spectrum, reduces pesticide application amount, reduces residual quantity of the pesticide on the crops, reduces the environment pollution, and delays the generation of disease resistance.