Application of Sarcaboside A in preparation of drug for treating acute gout
A technology for acute gout and drugs, applied in the field of preparation of drugs for the treatment of acute gout, can solve problems such as neutropenia, aplastic anemia, etc., and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics
Inactive Publication Date: 2013-10-23
丁圣雨
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Problems solved by technology
Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia
Method used
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Experimental program
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Effect test
Embodiment 1
[0017] Embodiment 1: the preparation of compound Sarcaboside A tablet involved in the present invention:
[0018] Take 20 grams of compound Sarcaboside A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0019] Embodiment 2: the preparation of compound Sarcaboside A capsule involved in the present invention:
[0020] Get 20 grams of compound Sarcaboside A, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0021] The following pharmacodynamic experiments will further illustrate its drug activity.
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The invention provides a new application of Sarcaboside A in medical science, and in particular provides application of Sarcaboside A in preparation of a drug for treating acute gout. The experimental result shows that Sarcaboside A has a protective effect on an acute gout model of urate-caused human vascular endothelial cell injuries and is capable of inhibiting the expression of ICAM (Intercellular Adhesion Molecule-1), and thus, Sarcaboside A can be used for preparing the drug for treating acute gout inflammation. The application of Sarcaboside A in preparation of the drug for treating the acute gout is disclosed by the invention for the first time. As the skeleton type is brand new and Sarcaboside A has unexpectedly strong activity in prevention and treatment of acute grout, the possibility that any enlightenments are given by other compounds does not exist. Sarcaboside A has prominent substantive features and has remarkable progress when being used for preventing and treating acute gout.
Description
technical field [0001] The present invention relates to the new application of Sarcaboside A in medicine, in particular to the application of Sarcaboside A in the preparation of medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammato...
Claims
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IPC IPC(8): A61K31/365A61P19/06
Inventor 丁圣雨
Owner 丁圣雨
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