Application of chukrasone B in preparation of medicine for treating acute gout
A technology for acute gout and medicine, applied in the application field of Chukrasone B in the preparation of medicine for treating acute gout, can solve the problems of aplastic anemia, neutropenia, etc., and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics
Inactive Publication Date: 2015-09-16
QINZHOU IND RES INST
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- Description
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AI Technical Summary
Problems solved by technology
Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0016] Embodiment 1: the preparation of the compound Chukrasone B tablet involved in the present invention:
[0017] Take 20 grams of compound Chukrasone B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0018] Embodiment 2: the preparation of the compound Chukrasone B capsules involved in the present invention:
[0019] Get 20 grams of compound Chukrasone B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0020] The following pharmacodynamic experiments will further illustrate its drug activity.
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The invention provides a new application of Chukrasone B in medical science, and particularly relates to an application of the Chukrasone B in the preparation of medicines for treating acute gout. Experimental research results show that the Chukrasone B has a protection effect on the human vascular endothelial cell damaged acute grout caused by monosodium urate and can be used for inhibiting the expression of ICAM-1 (Intercellular Cell Adhesion Molecule-1), therefore, the Chukrasone B can be used for the preparation of the medicines for treating acute gout inflammation. The application of the Chukrasone B in the preparation of the medicines for treating the acute gout is disclosed by the invention for the first time. As the skeleton type of the Chukrasone B belongs to a bran-new skeleton type and the Chukrasone B has unexpected strong activity on the prevention and treatment of the rheumatoid rhinitis, the possibility that other compounds provide revelation does not exist. The Chukrasone B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for preventing and treating the acute gout.
Description
technical field [0001] The present invention relates to the new application of Chukrasone B in medicine, in particular to the application of Chukrasone B in the preparation of medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammatory...
Claims
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IPC IPC(8): A61K31/365A61P19/06
Inventor 丁圣雨
Owner QINZHOU IND RES INST
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