Application of chukrasone B in preparation of medicine for treating acute gout

Abstract

The invention provides a new application of Chukrasone B in medical science, and particularly relates to an application of the Chukrasone B in the preparation of medicines for treating acute gout. Experimental research results show that the Chukrasone B has a protection effect on the human vascular endothelial cell damaged acute grout caused by monosodium urate and can be used for inhibiting the expression of ICAM-1 (Intercellular Cell Adhesion Molecule-1), therefore, the Chukrasone B can be used for the preparation of the medicines for treating acute gout inflammation. The application of the Chukrasone B in the preparation of the medicines for treating the acute gout is disclosed by the invention for the first time. As the skeleton type of the Chukrasone B belongs to a bran-new skeleton type and the Chukrasone B has unexpected strong activity on the prevention and treatment of the rheumatoid rhinitis, the possibility that other compounds provide revelation does not exist. The Chukrasone B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for preventing and treating the acute gout.

Description

technical field [0001] The present invention relates to the new application of Chukrasone B in medicine, in particular to the application of Chukrasone B in the preparation of medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammatory...

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

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