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Applications of Chukrasone A in medicines used for treating acute gout

A technology for acute gout and drugs, applied in the application field of Chukrasone A in the preparation of drugs for the treatment of acute gout, which can solve the problems of neutropenia, aplastic anemia, etc., and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics

Active Publication Date: 2013-11-06
FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

Method used

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  • Applications of Chukrasone A in medicines used for treating acute gout
  • Applications of Chukrasone A in medicines used for treating acute gout
  • Applications of Chukrasone A in medicines used for treating acute gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of the compound Chukrasone A tablet involved in the present invention:

[0018] Take 20 grams of compound Chukrasone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0019] Embodiment 2: the preparation of the compound Chukrasone A capsule involved in the present invention:

[0020] Get 20 grams of compound Chukrasone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0021] The following pharmacodynamic experiments will further illustrate its drug activity.

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Abstract

The invention provided new applications of Chukrasone A in medical science, and more specifically provides applications of Chukrasone A in preparation of medicines used for treating acute gout. Experiment research indicates that Chukrasone A has protective effect on an acute gout models with human blood vessel endothelium cell damages caused by urate, and is capable of restraining expression of ICAM-1. Therefore, Chukrasone A can be used for preparation of medicines to treat acute gout inflammation. Applications of Chukrasone A in preparation of medicines used for treating acute gout are disclosed for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and Chukrasone A has an unexpectedly high activity of preventing and curing acute gout, probability of other compounds giving any revelation for Chukrasone A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in preventing and curing acute gout.

Description

technical field [0001] The present invention relates to the new application of Chukrasone A in medicine, in particular to the application of Chukrasone A in the preparation of medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammatory...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61P19/06
Inventor 丁圣雨
Owner FENGJIE DONGYANG BUILDING MATERIALS CO LTD