Lung cancer preventing and treating composition extracted from selfheal and/or garden orache and application thereof in preparation of lung cancer preventing and treating medicine

A technology of Prunella vulgaris and composition, applied in the field of pharmaceutical composition

Inactive Publication Date: 2012-09-26
贾晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no literature report on the use of phenolic acids, flavonoids and triterpenoids in Prunella vulgaris as lung cancer prevention and treatment drugs and quality control methods

Method used

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  • Lung cancer preventing and treating composition extracted from selfheal and/or garden orache and application thereof in preparation of lung cancer preventing and treating medicine
  • Lung cancer preventing and treating composition extracted from selfheal and/or garden orache and application thereof in preparation of lung cancer preventing and treating medicine
  • Lung cancer preventing and treating composition extracted from selfheal and/or garden orache and application thereof in preparation of lung cancer preventing and treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Weigh 100 g of Prunella vulgaris, extract twice with 10 times the amount of 95% ethanol under reflux, and each time for 2 hours. The dregs were then refluxed with 10 times the amount of 75% ethanol to extract twice, each time for 2 hours. Use 10 times the amount of 40% ethanol to reflux extract the dregs for 2 times, each time for 2 hours; then use 10 times the amount of 10% ethanol for reflux extraction and extract twice, each time for 2 hours; filter the four parts of ethanol extraction respectively, and depressurize The ethanol was recovered and concentrated separately to obtain the extract. Dissolve the extract in water and load it on the processed SP825 or HP20 macroporous adsorption resin at a certain concentration, elute with distilled water and 10% ethanol respectively and discard the eluent, wash with 50% ethanol 8 times the volume of the resin bed Remove, collect 40%~60% ethanol eluate, concentrate under reduced pressure, and vacuum dry to obtain extract I (f...

Embodiment 2

[0084] Embodiment 2 is substantially the same as Example 1, but wherein the phenolic acid: flavonoids: the weight ratio of triterpenes is 9.5: 6.4: 5.0;

[0085] The weight ratio of caffeic acid: rosmarinic acid: rutin: quercetin: ursolic acid: oleanolic acid is 1.0: 14.7: 3.9: 1.0: 4.4: 1.4.

Embodiment 3

[0086] Embodiment 3 is basically the same as Example 1, but wherein the phenolic acid: flavonoids: the weight ratio of triterpenes is or 14.4: 9.5: 3.6;

[0087] The weight ratio of caffeic acid: rosmarinic acid: rutin: quercetin: ursolic acid: oleanolic acid is 1.0: 8.5: 5.8: 0.6: 4.1: 0.9.

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Abstract

The invention relates to lung cancer preventing and treating composition extracted from selfheal and / or garden orache and application thereof in preparation of lung cancer preventing and treating medicine. The composition comprises phenolic acid component, flavone component and triterpene component and is characterized in that the weight ratio of the phenolic acid component, flavone component andtriterpene component is 5-70: 2-60: 0.5-40. In optimum proposal, the phenolic acid component takes caffeic acid and rosmarinic acid as typical ingredients; the flavone component takes rutin and quercetin as typical ingredients; the triterpene component takes ursolic acid and oleanolic acid as typical ingredients; the weight ratio of the caffeic acid, rosmarinic acid, rutin, quercetin, ursolic acid and oleanolic acid is 0-20: 5-50: 2-40: 0-20: 0.25-20: 0.25-20. The invention overcomes the defect of control is difficult in the prior art, active component is separated, purified and enriched, process is simple; preventing and treating activity on lung cancer and related diseases is strong; and mass production can be carried out.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating lung cancer obtained from Prunella vulgaris and / or spinach, and the application of the composition in preparing the medicine for preventing and treating lung cancer. Background technique [0002] According to data published by the International Agency for Research on Cancer, lung cancer is the most common form of cancer worldwide. Studies have shown that the average survival time for lung cancer is 6.2 months. The 5-year survival rate of patients treated with non-surgical treatment was 7.8%. Patients in the surgery group survived on average 33 months, compared with 5.7 months in the chemotherapy group. The morbidity and mortality of lung cancer have been rising at an annual rate of 0.5%, which is higher than the average level in most developing countries. In my country, lung cancer ranks first among common malignant tumors...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/536A61P35/00A61K31/7048A61K131/00
Inventor 贾晓斌陈彦刘光敏封亮
Owner 贾晓斌
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