Use of Foveoeudesmenone in preparation of drug for treating acute gout

A technology for acute gout and drugs, applied in the application field of foveoeudesmenone in the preparation of drugs for the treatment of acute gout, which can solve problems such as aplastic anemia and neutropenia, and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics

Inactive Publication Date: 2016-02-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

Method used

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  • Use of Foveoeudesmenone in preparation of drug for treating acute gout
  • Use of Foveoeudesmenone in preparation of drug for treating acute gout
  • Use of Foveoeudesmenone in preparation of drug for treating acute gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of compound Foveoeudesmenone tablet involved in the present invention:

[0017] Get 20 grams of compound Foveoeudesmenone, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0018] Embodiment 2: the preparation of compound Foveoeudesmenone capsules involved in the present invention:

[0019] Get 20 grams of compound Foveoeudesmenone, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and make 1000 capsules.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1: Anti-acute gout inflammation experiment of Foveoeudesmenone:

[0022] 1: method

[0023] ① Solution preparation

[0024] Add 5 g of uric acid and 1000 ml of distilled water to boil, add 5% NaOH solution to adjust the pH to 7.4, stir, cool and crystallize to make sodium urate crystals (MSU). The prepared MSU 10 mg was autoclaved, added 10 ml of serum-free DMEM culture solution, and ground to form a 1 mg / ml DMEM solution. During the experiment, this solution was added with DMEM culture medium to form MSU solutions with different concentrations of DMEM.

[0025] Foveoeeudesmenone 2.5 mg, dissolved in dimethyl sulfoxide (DMSO), the final concentration of DMSO <0.02%, plus serum-free DMEM medium, prepared to a concentration of 2.5ug / ml, 25ug / ml, 250ug / ml.

[0026] Positive drug indomethacin 2.0mg, the method is the same as Foveoeudesmenone, the preparation concentration is 20ug / ml.

[0027] ② In vitro culture of vascular endothelial cells

[0028...

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PUM

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Abstract

The invention provides a novel use of Foveoeudesmenone in medical science and concretely relates to a use of Foveoeudesmenone in preparation of a drug for treating acute gout. An experiment research result shows that Foveoeudesmenone has protection effects on a urate-caused human vascular endothelium injury and can inhibit ICAM-1 expression and thus Foveoeudesmenone can be used for preparation of a drug for treating acute gout inflammation. The use of Foveoeudesmenone in preparation of a drug for treating acute gout is disclosed first. The skeleton type of the Foveoeudesmenone belongs a novel skeleton type, the Foveoeudesmenone has unexpected acute gout prevention and treatment activity, is free of any enlightenment provided by other compounds and has prominent substantive features, and the use of Foveoeudesmenone in prevention and treatment on acute gout has substantial progress.

Description

technical field [0001] The present invention relates to a new application of compound Foveoeudesmenone, in particular to the application of Foveoeudesmenone in the preparation of medicines for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to precipitate and crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P19/06
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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