Application of Gypensapogenin A in medicine for treating acute gout
A technology for acute gout and drugs, applied in the field of application of Gypensapogenin A in the treatment of acute gout drugs, can solve problems such as neutropenia, aplastic anemia, etc., and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics
Inactive Publication Date: 2013-08-28
JIANGSU DINGBANG BIOMASS ENERGY MACHINERY
View PDF0 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0017] Embodiment 1: the preparation of the compound Gypensapogenin A tablet involved in the present invention:
[0018] Take 20 grams of compound Gypensapogenin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.
Embodiment 2
[0019] Embodiment 2: The preparation of the compound Gypensapogenin A capsules involved in the present invention:
[0020] Get 20 grams of compound Gypensapogenin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.
[0021] The following pharmacodynamic experiments will further illustrate its drug activity.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention provides new application of Gypensapogenin A in the medicine, and in particular relates to application of Gypensapogenin A in preparing a medicine for treating acute gout. Experiment research results indicates that Gypensapogenin A has the protective effect on acute gout models with human blood vessel endothelium cells damage cuased by urate, and restrains ICAM (intercellular adhesion molecule)-1 expression, so that Gypensapogenin A can be used for preparing the medicine for treating acute gout inflammation. The application of Gypensapogenin A in preparing the medicine for treating acute gout, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the acute gout preventing activity of Gypensapogenin A isextremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin A has outstanding actual characteristics. Meanwhile, Gypensapogenin A has outstanding progress when being used for preventing and treating acute gout.
Description
technical field [0001] The present invention relates to the new application of Gypensapogenin A in medicine, in particular to the application of Gypensapogenin A in the preparation of medicines for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inf...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P19/06A61P29/00
Inventor 王泽正俞骁吴俊华
Owner JIANGSU DINGBANG BIOMASS ENERGY MACHINERY
PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.
