Application of Gypensapogenin A in medicine for treating acute gout

Abstract

The invention provides new application of Gypensapogenin A in the medicine, and in particular relates to application of Gypensapogenin A in preparing a medicine for treating acute gout. Experiment research results indicates that Gypensapogenin A has the protective effect on acute gout models with human blood vessel endothelium cells damage cuased by urate, and restrains ICAM (intercellular adhesion molecule)-1 expression, so that Gypensapogenin A can be used for preparing the medicine for treating acute gout inflammation. The application of Gypensapogenin A in preparing the medicine for treating acute gout, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the acute gout preventing activity of Gypensapogenin A isextremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin A has outstanding actual characteristics. Meanwhile, Gypensapogenin A has outstanding progress when being used for preventing and treating acute gout.

Description

technical field [0001] The present invention relates to the new application of Gypensapogenin A in medicine, in particular to the application of Gypensapogenin A in the preparation of medicines for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inf...

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

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