Application of Aphanamixoid A in medicines curing acute gout
A technology for acute gout and medicine, applied in the field of application of Aphanamixoid A in the preparation of medicines for the treatment of acute gout, which can solve problems such as aplastic anemia and neutropenia, and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics
Inactive Publication Date: 2013-06-05
吴俊华
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AI Technical Summary
Problems solved by technology
Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0017] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:
[0018] Get 20 grams of compound Aphanamixoid A, add 180 grams of conventional adjuvants for preparing tablets, mix evenly, and make 1000 tablets on a conventional tablet press.
Embodiment 2
[0019] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:
[0020] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0021] The following pharmacodynamic experiments will further illustrate its drug activity.
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The invention provides a new use of Aphanamixoid A in medical science, and particularly relates to application of preparation of the Aphanamixoid A in medicines curing acute gout. Experiment research indicates that the Aphanamixoid A has protective effect on an acute gout model in which urate causes damage of vascular endothelial cell, and restrains expression of intercellular cell adhesion molecule (ICAM)-1. Therefore, the Aphanamixoid A can be used for preparation of the medicines curing acute gout inflammation. Use of the Aphanamixoid A in preparation of the medicines curing the acute gout is made public for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and the Aphanamixoi A has an unexpectedly high activity of preventing and curing the acute gout, probability of other compounds giving any revelation for the Aphanamixoi A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in preventing and curing the acute gout.
Description
technical field [0001] The present invention relates to the new application of traditional Chinese medicine extract Aphanamixoid A in medicine, in particular to the application of Aphanamixoid A in preparing medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. ...
Claims
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IPC IPC(8): A61K31/365A61P19/06
Inventor 冯怡李丽丽龚霞吴俊华
Owner 吴俊华
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