New mutation sites associated with streptomycin resistance in Mycobacterium tuberculosis and their applications
A technique for Streptomycin bacillus and branch of tuberculosis, which is applied in the detection/testing of microorganisms, DNA/RNA fragments, recombinant DNA technology, etc. It can solve problems such as time-consuming, affecting patient diagnosis and treatment, and increasing the chance of drug-resistant strains spreading. Achieve the effects of shortening the diagnosis time, saving treatment time and cost, and improving the level of molecular detection
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[0025] 1. Prediction of base mutation sites associated with STR drug resistance
[0026] First, using deep-sequencing technology, the whole genome of 161 strains of Mycobacterium tuberculosis from China was sequenced, including 44 strains of sensitive strains, 94 strains of multidrug-resistant strains (MDR), and 23 strains of extensively drug-resistant strains (XDR). The H37Rv standard Mycobacterium tuberculosis strain genome sequence was used as a control for bioinformatics analysis, and a batch of new genes closely related to drug resistance and single nucleotide polymorphism (SNP) sites in the intergenic region (IGR) were found, among which The single-base mutation site in the intergenic region Rv1194c-Rv1195 has a high correlation with streptomycin (STR) resistance, with a P value of 0.002, as shown in Table 1.
[0027] Table 1 Correlation between the single base mutation site in the intergenic region Rv1194c-Rv1195 and different drug resistance
[0028]
[0029] Table...
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