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36results about How to "Save treatment time" patented technology

Impacted tooth appliance

An impacted tooth appliance including a micropin bone anchor with a quadrilateral aperture formed therein, a rigid apertured ribbon secured to the impacted tooth by means of a rotatable bracket secured to the tooth, the ribbon pivoted on the bracket, and the ribbon and the micropin interconnected by means of spring-biased quadrilateral wire.
Owner:YAZDI MOHAMADREZA

Position independent catheter

A catheter for treating tissue is disclosed, the catheter having slotted openings on a circumference of its distal portion, wherein each slotted opening spans at least about 25% of the circumference of the catheter. The disclosed catheter is capable of treating a variety of tissue in a variety of configurations. For example, in an ablation catheter of the disclosed invention, the slotted openings on the distal portion allow the ablation catheter to create effective lesions in both the pulmonary veins and the posterior wall of the left atrium. The ablation catheter preferably carries a conductive medium to help deliver ablation energy (e.g., RF) to the tissue being ablated. The configuration of the catheter permits ablation to be conducted in many varieties and geometric orientations independently of the tissue orientation. Also disclosed is a method of ablating tissue using catheter with slotted openings.
Owner:ST JUDE MEDICAL ATRIAL FIBRILLATION DIV

Impacted tooth appliance

An impacted tooth appliance including a micropin bone anchor with a quadrilateral aperture formed therein, a rigid apertured ribbon secured to the impacted tooth by means of a rotatable bracket secured to the tooth, the ribbon pivoted on the bracket, and the ribbon and the micropin interconnected by means of spring-biased quadrilateral wire.
Owner:YAZDI MOHAMADREZA

Aqueous one step type lubricanting agent for efficient cold forging

A new aqueous lubricant of one process type used for high efficient cold forging of metallic materials is disclosed. The aqueous lubricant produces less industrial waste than conventional process, requires simple processing steps and provides improved lubricative performance. The aqueous lubricant of the invention is comprising (A) a water soluble inorganic salt, (B) wax and (C) a metal salt of a fatty acid, those are dissolved or dispersed in water, and the ratio of (B) / (A) is 0.60~0.70 and the ratio of (C) / (A) is 0.1~0.3. The water soluble inorganic salt may be a sulfates, silicates, borates, molybdates and tungstates. The wax may be a synthetic wax of which melting point is in a range of 70~150° C. The metal salt of a fatty acid may be a product prepared by reacting of C12~C26 saturated fatty acids with metal selected from zinc, calcium, barium, aluminum magnesium and lithium.
Owner:HONDA MOTOR CO LTD +1

Method for determining pectin content in plant sample

Disclosed is a method for determining pectin content in a plant sample, comprising the following steps: 1) adding an acidic alcohol solution to the plant sample, then heating the resulting mixture to reflux in a water bath, followed by a first filtration; 2) soaking the filtered residue obtained from the first filtration with an acidic solution, then heating the resulting mixture to reflux in a water bath, followed by a second filtration, then bringing to volume after cooling, obtaining filtrate for later use; 3) adding an acetic acid / sodium acetate buffer solution to treat the filtered residue obtained from the second filtration, then adding a pectinase solution and heating the resulting mixture under vibration in a water bath, followed by a third filtration to obtain a filtrate for later use; 4) sequentially adding an acetic acid / sodium acetate buffer solution and a pectinase solution to the filtrate obtained in step 2) and heating the resulting mixture under vibration in a water bath to obtain an enzymatic hydrolysate, then adding the filtrate obtained in step 3) to the enzymatic hydrolysate followed by bringing to volume, obtaining a test solution; and 5) drawing the test solution into a continuous flow analyzer to perform analysis. The method disclosed has the advantage of providing accurate analysis results.
Owner:CHINA TOBACCO GUANGDONG IND

New mutation site related to isoniazide resistance of mycobacterium tuberculosis and application thereof

The invention discloses a new mutation site related to isoniazide resistance of mycobacterium tuberculosis and an application thereof. The new mutation site is positioned at a 1673425th site of a standard strain H37Rv genome, that is a 126th base in an intergenic region of Rv1482c to Rv1483*, and the generated point mutation comprises that a base C is mutated into a base T or a base A. The found new mutation site can be used as a detection target applied in detection of the isoniazide resistance of mycobacterium tuberculosis, improves the molecular detection level of the isoniazide resistance of mycobacterium tuberculosis, shortens the diagnosis time of patients, and saves the treating time and cost for the patients. The mycobacterium tuberculosis drug-resistant mutation site is explained to possibly occur in a non-coding region, the base mutation of the intergenic region is prompted to be possibly related to the drug resistance, and a drug-resistant biomarker also exists. The invention provides a new idea for finding out a new and more effective mycobacterium tuberculosis drug-resistant molecular marker.
Owner:广东省结核病控制中心

Sphenoid needle type electrode for electroencephalogram detector

The invention provides a sphenoid needle type electrode for an electroencephalogram detector. The electrode comprises an electrode needle, a wiring terminal, an electrode connecting wire and an electroencephalogram tester, wherein the wiring terminal and the electrode needle are connected sequentially on the electrode connecting wire of the electroencephalogram tester; the electrode needle and the wiring terminal are fixedly or movably connected; the wiring terminal and the electrode connecting wire are fixedly connected; and the electrode connecting wire and the electroencephalogram tester are connected. The sphenoid needle type electrode has the characteristics of reasonable structure, simple operation, acupoint hit positioning, strong pertinence, high accuracy, accurate data, quick confirmed diagnosis, good effect, low cost, no pain of a patient, small economical burden and the like, and is simple to operate. Particularly, a needle type electrode structure is adopted, an acupoint hit positioning monitor technology is realized, the accuracy of monitoring data is improved to quickly diagnose the symptom of the patient, carrying is convenient, the accuracy of data collection is improved, the misdiagnose rate is reduced, and time and cost for medical treatment are saved, so that the electrode is an ideal mating electrode for a dedicated electroencephalogram tester for electroencephalogram data collection.
Owner:卢佩林 +1

Paracentesis needle frame

ActiveUS20190069923A1Conveniently and accurately adjustConvenient and efficient installationUltrasonic/sonic/infrasonic diagnosticsCannulasParacentesisFixed frame
A needle guide holder, which is used for a fixing medical puncture needle and a ultrasonic probe, comprises a holder body (1a, 1b) and a fixing device (2a, 2b) used in cooperation with the holder body (1a, 1b). The fixing device (2a, 2b) is mounted onto the holder body (1a, 1b) and provided with a weakening portion (23a, 23b). The needle guide holder is designed to be disposable, thereby avoiding the possibility of cross-infection caused by using the same needle guide holder on different patients. The needle guide holder can be used on one and same patient to perform a number of treatments just through the replacement of a sliding frame and without replacing the fixing device and a fixing frame. In a treatment process, the puncture needle is left in the body for a subsequent treatment, while the needle guide holder and the ultrasonic probe can be removed from the human body.
Owner:WANG QIN

Fullerene polyaza ligand transition metal complex for magnetic resonance imaging and photodynamic therapy, preparation method, application and products

ActiveCN108017781AEfficient magnetic resonance effectPhototoxicOrganic chemistryPhotodynamic therapyLive animalAntioxidant
The present invention discloses a fullerene polyaza ligand transition metal complexe for magnetic resonance imaging and photodynamic therapy, a preparation method, application and products. The fullerene polyaza ligand transition metal complex in the present invention is obtained according to the following steps: performing a reaction by taking Boc-NH-PEG-COOH and tri-t-butyl-1,4,7,10-tetraazacyclododeca as raw materials, removing the Boc group in the obtained intermediate, then complexing the treated intermediate and a transition metal compound, and then reacting the obtained complex with a fullerene derivative to obtain the fullerene polyaza ligand transition metal complex. The fullerene polyaza ligand transition metal complex has a high relaxation rate, high-efficiency magnetic resonance effect and high-accuracy magnetic resonance imaging diagnosis and photodynamic therapeutic effect, can be used for preparing magnetic resonance imaging contrast agents, antioxidants, photodynamic therapy agents and drug carriers, and have important clinical value for achieving targeted drug delivery, live-animal tracking, drug therapy, and prognosis monitoring.
Owner:BEIJING FUNAKANG BIOTECH CO LTD

Radio frequency treatment to phytosanitize wood packaging materials used in international shipping

A method for treating wood packaging materials using Radio Frequency heating includes the steps of heating wood packaging materials using RF heating and applying a pressure before the heating or incrementally applying a pressure during the heating until a temperature of the wood packaging materials reaches at least 60° C. and that temperature is maintained for at least 1 minute.
Owner:US SEC AGRI +1

Injection support and injection thrombolysis system including same

The invention relates to the technical field of medical instruments, and discloses an injection support and an injection thrombolysis system including the same. The injection support comprises a drugdelivery pipe, a support body capable of elastically expanding in radial direction and a thrombus filter screen, wherein the support body is fixedly arranged on the drug delivery pipe; the support body comprises a plurality of elastic pipes which form the support structure; the elastic pipes are communicated with the drug delivery pipe; and a plurality of drug injection holes are formed in the elastic pipes; and the thrombus filter screen is fixedly arranged on the drug delivery pipe and is positioned at the far end of the support body. According to the embodiment, the injection support capable of elastically expanding is released at the position of thrombus, so that the injection support can inject a thrombolytic agent after being embedded into the thrombus, the thrombolytic agent can directly and accurately act on the thrombus in a large area, the thrombolytic efficiency can be improved, and the thrombolytic agent and the treatment time can be saved.
Owner:SHANGHAI TENDFO MEDICAL TECH CO LTD

Medicine storage device with definite classification

InactiveCN107985751ADefinitely depositEasy to storeLidsRigid containersEngineering
The invention relates to the technical field of medicine storage devices, and discloses the medicine storage device with definite classification. The device comprises a tank body, a top cover is clamped at the top end of the tank body, and the interior of the tank body is divided into a first chamber, a second chamber, a third chamber and a fourth chamber through a first vertical plate and a second vertical plate; and the bottom of inner cavity of the first chamber is provided with a box body through a formed groove, a hanging lug is fixedly arranged on the side, located inside the bottom opening of the first chamber, of the box body, a barrel body is placed at the part, right above the box body, in the first chamber through an L-shaped partition plate, and a separating device is fixedly arranged inside the barrel body. According to the medicine storage device with the definite classification, a traction rope is arranged so that a cover plate can be pulled up, therefore, the purpose ofconveniently taking the medicine is achieved, meanwhile, the same purpose can be achieved by rotating a movable frame, convenience and quickness are achieved, and the storage amount is also large andthe storage is clear.
Owner:季柳莹

Tunnel collapse treatment method

The invention relates to the technical field of tunnel engineering construction, in particular to a tunnel collapse treatment method. The tunnel collapse treatment method comprises the steps that back pressing backfilling is conducted on a collapse body, back pressing is conducted on a collapse section and a traction section, and the collapse body is preliminarily stabilized; a primary support section is reinforced; a collapse cavity is backfilled, a collapse section arch frame, spraying concrete, backfilling bubble mixed light soil in the collapse cavity of the collapse section are replaced, and the arch frame and spraying concrete in a traction section are replaced. When the tunnel collapse treatment method is adopted for primary support lateral collapse treatment, on one hand, construction safety can be guaranteed, the engineering cost is reduced, the treatment time can be greatly saved, and good economic benefits and social benefits are obtained.
Owner:XINJIANG BEIXIN ROAD & BRIDGE GRP

Surgical anoscope

The invention relates to a surgical anoscope which comprises a lens barrel body, a moving handle and a self-locking coil. The lens barrel body comprises a first lens barrel and a second lens barrel which are symmetrically arranged and can form a cylinder, a thread clamp for fixing the self-locking coil is arranged on the lens barrel body, the moving handle can control opening and closing of the first lens barrel and the second lens barrel, a clamping hole is formed in the upper end of the lens barrel body, a first guide shaft and a second guide shaft are parallelly arranged inside the lens barrel body, a first fixer is arranged at the end of the first guide shaft, a second fixer is arranged on the second guide shaft and can horizontally move along the second guide shaft, and a boosting clamping ring is arranged on the second guide shaft. The surgical anoscope is simple in structure and compact in design; the clamping hole is formed in the anoscope, can be used for clamping haemorrhoidsafter observation and can cooperate with the self-locking coil for haemorrhoids loop ligature, and haemorrhoids loop ligature can be completed by only one person, so that observation and treatment time is saved; valuable medical consumables are not needed, so that treatment cost is low.
Owner:无锡市惠山区中医医院

Multipurpose pain rehabilitation instrument

InactiveCN106334264AEasy to useInappropriate to useUltrasound therapyExternal electrodesSignal generatorPain rehabilitation
The invention discloses a multipurpose pain rehabilitation instrument. The instrument comprises a portable host, a power line, multiple groups of electrodes and multiple groups of transmission lines. The portable host is provided with multiple groups of treatment signal generators and an output electrode. The treatment signal generators, outlets, the transmission lines and the electrodes form one-to-one correspondence respectively. Each treatment signal generator is connected to the corresponding electrode through the corresponding outlet and the corresponding transmission line. The electrodes and electrode connecting lines are detachably assembled together. The electrodes are adjustably stuck to a affected part position which needs to recover. Through different signal frequency adjusting, different treatment signals can be generated so as to drive different electrodes; one therapeutic instrument host is used to cooperate with the different electrodes and the transmission lines so as to complete a plurality of rehabilitation treatment schemes; one instrument has many functions and does not need to be installed on an apparatus bench so that space is saved, and the instrument can be moved conveniently.
Owner:天津内川医疗科技有限公司

Traditional Chinese medicine composition for treating collum femoris fracture and preparation method thereof

The invention is applicable to the technical field of traditional Chinese medicine preparation and provides a traditional Chinese medicine composition for treating collum femoris fracture. The traditional Chinese medicine composition is prepared from, by weight, 100-200 parts of herbs of tuberculate speranskia, 50-120 parts of sanguis draxonis, 50-120 parts of frankincense, 50-120 parts of myrrh, 50-120 parts of radix angelica sinensis, 50-150 parts of ground beetles, 50-150 parts of lignum sappan, 50-150 parts of pheretima, 50-80 parts of scorpio, 50-80 parts of ippocampus, 50-80 parts of zaocys, 50-80 parts of cortex eucommiae, 50-80 parts of ramulus cinnamomi, 50-80 parts of radix dipsaci, 50-80 parts of radix paeoniae rubra, 20-80 parts of flos carthami, 20-60 parts of radix achyranthis bidentatae and 10-50 parts of radix saposhnikoviae. The cure rate reaches 95%. The invention further relates a preparation method of the composition, the process is simple and scientific, mechanical operation is achieved easily, both symptoms and root causes of diseases are treated through the pesticide effect, treatment time is reduced, treatment cost is lowered, and side effects brought by western medicine are also lowered.
Owner:潍坊德善堂中医骨伤病研究所

Externally-applied pharmaceutical composition for treating facial paralysis and preparation and application method of externally-applied pharmaceutical composition for treating facial paralysis

InactiveCN108524882APromote muscle developmentPromotes Cell Regenerative PropertiesNervous disorderAnthropod material medical ingredientsScolopendraDrugs prescriptions
The invention discloses an externally-applied pharmaceutical composition for treating facial paralysis and a preparation and application method of the externally-applied pharmaceutical composition fortreating facial paralysis. The method includes: preparing raw materials including, by weight, 1.5-4.5 parts of fructus crotonis, 2-4 parts of herba schizonepetae, 2-4.5 parts of mylabris, 0.5-2 partsof scolopendra and 0.5-3 parts of radix glycyrrhizae; preparing auxiliary materials including 1-2.5 parts of bombyx batryticatus, 1.5-3 parts of radix astragali, 0.5-1.5 parts of musk and 1.5-3.5 parts of radix saposhnikoviae; implementing and applying proportional composition (preferably ointment) to protect key prescription medicines; sequentially mashing with a fresh willow stick into a semi-finished product, adding into standby medicinal powder, mashing to make the ointment, and using gauze to make clinically-acceptable medicinal patches for standby application; or sequentially mashing with the fresh willow stick into a semi-finished product, adding into standby medicinal powder, mashing to make the ointment, drying in the shade, grinding into powder for standby application, and applying externally.
Owner:秦兆云 +1

Press needles with an alignment structure

Provided is an press needles with an alignment structure having a conductor and multiple needles. The conductor having two opposite ends has an acupuncture area and a holding area. The acupuncture area is located at one end of the conductor, and the holding area is located at the other end of the conductor. The needles are sequentially aligned at a side of the conductor. Therefore, the alignment structure offers the patient better treatments and decreasing the period of treatment.
Owner:HO WU CHI +1

Mobile health intelligent medical guide system and method thereof

The present invention discloses a mobile health intelligent medical guide system and method thereof. The method comprises: collecting patient chief complaint by use of a mobile terminal, sending the patient chief complaint to a cloud server through the mobile phone device internet, analyzing and processing the patient chief complaint by use of the keyword extraction, text word segmentation, fuzzy matching and sorting recommendation technologies based on a medical knowledge base, automatically generating a disease examination result, and generating an intelligent medical guide result to be fed back to the mobile terminal in combination with the doctor information; and then optimizing the disease examination result and the intelligent medical guide result one by one until the patient ends the query or the diagnosis result achieves the optimum. The system can assist the patient to perform self-helped disease examination and medical guide in the mobile environment.
Owner:HEFEI UNIV OF TECH

Potable multifunctional pain treatment instrument

The invention discloses a potable multifunctional pain treatment instrument. The potable multifunctional pain treatment instrument comprises a portable host machine, a probe bracket, a plurality of groups of probes and a plurality of groups of transmission lines, wherein the portable host machine is provided with a plurality of treatment signal drivers and a plurality of output ports; the treatment signal drivers, the output ports, the transmission lines and the probes are in one-to-one correspondence to one another; each treatment signal driver is connected with the corresponding probe through the corresponding output port and the corresponding transmission line; the probes are detachably assembled with the probe bracket; the probe bracket is adjustably clamped on two sides, around a wounded part, of a body. Different treatment signals can be generated to drive different probes; various treatment schemes can be completed by virtue of the host machine, the probe bracket, different probes and different transmission lines of the same treatment instrument; the potable multifunctional pain treatment instrument is multi-purpose, does not need to be mounted on an instrument table, is space-saving, and is convenient to move.
Owner:ISRAEL CHASESUN MEDICAL SCI & TECH DEV TIANJIN

Radio frequency treatment to phytosanitize wood packaging materials used in international shipping

A method for treating wood packaging materials using Radio Frequency heating includes the steps of heating wood packaging materials using RF heating and applying a pressure before the heating or incrementally applying a pressure during the heating. The wood packaging materials are heated in a RF operating unit that has a sealed chamber with an inner surface and a liner cover a majority of the inner surface, the liner having a heat-reflective inner face and an insulation layer between the inner face and the inner surface.
Owner:PENN STATE RES FOUND

Lead-out structure of negative pressure coupling electric field dressing

The invention discloses a negative pressure coupling electric field dressing leading-out structure. The negative pressure coupling electric field dressing comprises an electric field device and a negative pressure device, wherein the electric field device is used for applying an electric field between normal wound edge skin and a wound surface, and the negative pressure device is used for applying negative pressure to the wound surface and draining wound surface seepage; the leading-out structure comprises a connector connected with the treatment instrument through a first lead and further comprises a plurality of joints connected with the negative pressure coupling electric field dressings through second leads, and the connector is provided with a plurality of interfaces connected with the joints in a matched mode. The negative pressure coupling electric field dressing leading-out structure has the advantages that the structure is simple, connection is convenient, tedious parameter setting steps are not needed, and the negative pressure coupling electric field dressing leading-out structure can be used for dressing electrical and negative pressure leading-out at the same time.
Owner:长沙海润生物技术有限公司

A dna marker for detecting drug resistance of mycobacterium tuberculosis and its application

The invention discloses a DNA marker for detecting the drug resistance of mycobacterium tuberculosis and application of the DNA marker. It is found that mutant protein Rv2783cD67N has the DNA polymerase activity without dependence on a DNA template, is not suppressed by POA and has the phosphorolysis singe-stranded DNA (SS DNS) activity; besides, the mutant protein Rv2783cD67N can not be combined with POA; by means of the locus mutation, the drug resistance of mycobacterium tuberculosis on PZA can be remarkably caused, the locus can serve as a mark locus for molecular diagnosis of PZA drug resistance of mycobacterium tuberculosis, and the detection rate and the precision of mycobacterium tuberculosis with PZA drug resistance can be easily improved. The diagnosis time of patients can be effectively shortened, and the treatment time and cost of patients can be saved. The DNA marker for detecting the drug resistance of mycobacterium tuberculosis and application of the DNA marker provide a new thought for finding new and more effective tuberculosis drug resistance molecular markers.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI

A plant monomer composition for inhibiting tumor cell growth and its preparation method and application

The invention discloses a plant monomer composition for inhibiting the growth of tumor cells, its preparation method and application. The plant monomer composition is composed of the following plant monomers in parts by weight: 0.1-10 parts by weight of 20(R)-ginsenoside Rg3, 7-30 parts by weight of oridonin and 5-30 parts by weight of ganoderma polysaccharide composition. Preferably, the plant monomer composition is composed of the following plant monomer-phospholipid complex in parts by weight: 0.1 to 10 parts by weight of 20(R)-ginsenoside Rg3-phospholipid complex, oridonin-phospholipid It consists of 7-30 parts by weight of the complex and 5-30 parts by weight of the ganoderma polysaccharide-phospholipid complex. In vitro and in vivo tumor inhibition experiments have proved that the plant monomer composition of the present invention has an effective rate of inhibiting tumor proliferation of 100%, and the inhibition rate is 86.13%. In conclusion, the plant monomer composition of the present invention exhibits a significant anti-proliferation effect on tumors, and is a good drug choice for clinical treatment of solid tumors.
Owner:陈炯

Method for determining pectin content in plant sample

A method for determining pectin content in a plant sample includes: 1) adding an acidic alcohol solution to the plant sample, heating in a water bath and filtration; 2) soaking residue from step 1 with an acidic solution, heating in a water bath, a second filtration, bringing to volume after cooling and obtaining filtrate; 3) adding an acetic acid / sodium acetate buffer solution to residue of step 2, adding a pectinase solution, heating under vibration in a water bath, and a third filtration to obtain a filtrate; 4) adding an acetic acid / sodium acetate buffer solution and a pectinase solution to filtrate from step 2, heating the mixture under vibration in a water bath to obtain an enzymatic hydrolysate, adding filtrate obtained in step 3 to the enzymatic hydrolysate, bringing to volume, and obtaining a test solution; 5) drawing the test solution into a continuous flow analyzer to perform analysis.
Owner:CHINA TOBACCO GUANGDONG IND

Dressing for negative voltage electric field coupling strong oxygen treatment

The invention discloses a dressing for negative pressure electric field coupling strong oxygen therapy, which comprises a first film layer covering a wound surface and a wound edge, and the first film layer is communicated with negative pressure equipment and strong oxygen equipment; the edge of the first film layer is provided with a flexible first closed ring which is folded towards the center of the first film layer, the suspended edge of the first closed ring is attached to the wound edge under high pressure, and a closed area is defined by the suspended edge of the first closed ring, the wound surface and the first film layer; the electric field device comprises a positive electrode arranged at the wound edge, a negative electrode arranged at the center of the wound surface and a power supply for supplying power to the positive electrode and the negative electrode. The dressing for negative pressure electric field coupling strong oxygen treatment has the advantages that the structure is simple, negative pressure, an electric field and strong oxygen are reasonably combined, and the treatment time is shortened.
Owner:长沙海润生物技术有限公司

An air-heating circulation heating type quicksand bed

The invention provides a circulating air-heating drift sand bed. The circulating air-heating drift sand bed comprises a bed body, wherein the bed body is divided into a sand therapy zone and an equipment zone through a partition; the sand therapy zone adopts a semi-closed structure with an open top; a sand pit is arranged inside the sand therapy zone; a first radiating tube, a second radiating tube and a third radiating tube are laid below the sand pit; a sand bath device is arranged above the bed body, and can provide sand bath for a patient; a heating unit, a gas pressurizing unit and a temperature control unit are arranged inside the equipment zone; three top plates are arranged above the sand therapy zone, and can be flexibly spliced and assembled into a mattress or a worktable. The circulating air-heating drift sand bed heats the sand pit in a circulating electric heating way so as to substitute the conventional sand therapy, has a good therapeutic effect, and saves the therapeutic cost and the therapeutic time of a rheumatoid patient.
Owner:孙敏煜

New mutation sites associated with streptomycin resistance in Mycobacterium tuberculosis and their applications

The invention discloses a new mutation site related to streptomycin resistance of Mycobacterium tuberculosis and its application. The new mutation site is located at the 1338631st position of the standard strain H37Rv genome, that is, the 47th base of the intergenic region Rv1194c‑Rv1195 , the point mutation that occurs is the mutation of base C to A. The new mutation site found in the present invention can be used as a detection target in the detection of streptomycin resistance of Mycobacterium tuberculosis, improve the molecular detection level of streptomycin resistance of Mycobacterium tuberculosis, shorten the diagnosis time of patients, save Patient treatment time and cost. The invention shows that the tuberculosis drug-resistant mutation site may also occur in the non-coding region, suggesting that the base mutation in the intergenic region may also be related to drug resistance, and there are also drug-resistant biomarkers. The invention provides a new idea for finding new and more effective tuberculosis drug resistance molecular markers.
Owner:广东省结核病控制中心
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