A plant monomer composition for inhibiting tumor cell growth and its preparation method and application

Abstract

The invention discloses a plant monomer composition for inhibiting the growth of tumor cells, its preparation method and application. The plant monomer composition is composed of the following plant monomers in parts by weight: 0.1-10 parts by weight of 20(R)-ginsenoside Rg3, 7-30 parts by weight of oridonin and 5-30 parts by weight of ganoderma polysaccharide composition. Preferably, the plant monomer composition is composed of the following plant monomer-phospholipid complex in parts by weight: 0.1 to 10 parts by weight of 20(R)-ginsenoside Rg3-phospholipid complex, oridonin-phospholipid It consists of 7-30 parts by weight of the complex and 5-30 parts by weight of the ganoderma polysaccharide-phospholipid complex. In vitro and in vivo tumor inhibition experiments have proved that the plant monomer composition of the present invention has an effective rate of inhibiting tumor proliferation of 100%, and the inhibition rate is 86.13%. In conclusion, the plant monomer composition of the present invention exhibits a significant anti-proliferation effect on tumors, and is a good drug choice for clinical treatment of solid tumors.

Description

technical field [0001] The invention relates to a plant monomer composition and its preparation method and application, in particular to a plant monomer composition for inhibiting tumor cell growth, its preparation method and application. The invention belongs to the technical field of medicine. Background technique [0002] The official journal of the American Cancer Society "Journal of Cancer for Clinicians" published the "Global Cancer Statistics 2018" report online. In 2018, there are estimated to be 18.1 million new cancer cases and 9.6 million cancer deaths worldwide, which has become second only to cardiovascular diseases. the second killer of human beings. The number of new cases in my country accounted for 3.804 million cases and the number of deaths accounted for 2.296 million cases. At present, the total number of cancer patients in the country is about 5.5 million. [0003] There are many kinds of anti-tumor drugs and treatment methods in the world, including ...

AI Technical Summary

Problems solved by technology

[0005] ① Due to the low solubility of some plant anti-tumor active ingredients (plant monomers) (such as paclitaxel and Rubescensine A, which have good anti-tumor effects), the bioavailability of the drug is extremely poor, including low absorption rate in the body and half-life time short, the effective therapeutic concentration is not enough, etc., resulting in poor anti-tumor treatment effect, which can not be practically applied in clinical practice and become a difficulty

[0006] ②The vast majority of non-targeted anti-tumor agents do not have specific inhibitory effect on tumor cells (such as anti-tumor chemotherapy drugs, untreated natural anti-tumor drugs, etc.). At the same time, it also causes damage to the normal tissues of the whole body, with side effects including strong gastrointestinal reactions, hair loss, leukopenia, etc.

[0007] ③Because tumorigenesis is the result of multiple gene mutations, the pathological mechanism is very complex, relying on a single anti-tumor drug component to attack only a certain part of the tumor cells, cannot comprehensively and effectively inhibit the growth of tumor cells, its effectiveness in inhibiting tumor cells and Relatively low inhibition rate, high recurrence and metastasis rate

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