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Sesquiterpene and preparation method and use of sesquiterpene

A technology of sesquiterpene and combined application, applied in the field of chemical separation of natural medicines

Active Publication Date: 2014-06-25
成都格纯生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no report on the extraction, isolation and identification of the sesquiterpene as shown in the structural formula (I) from the genus Eupatorium adenophorum of the genus Asteraceae of the order Compositae

Method used

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  • Sesquiterpene and preparation method and use of sesquiterpene
  • Sesquiterpene and preparation method and use of sesquiterpene

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Take the dried Eupatorium adenophorum whole herb dry powder, soak it with ethyl acetate for 3 days, filter to obtain the soaking solution; then soak it with ethyl acetate for 3 days, filter to get the second soaking solution; combine the two soaking solutions, Concentrate to dryness to obtain extract. Then the obtained extract is mixed with silica gel, and through silica gel column chromatography, using sherwood oil / acetone as eluent, the ratio of eluent is sherwood oil / acetone from 30:1,20:1,10:1, 5:1, the compound of the present invention was obtained.

Embodiment 2

[0019] Take the dry powder of Eupatorium adenophorum whole herb, soak it with ether for 3 days, filter to obtain the soaking solution; then soak it with ether for 3 days, filter to get the second soaking solution; combine the two soaking solutions, concentrate to dryness, Get the extract. Then the obtained extract is mixed with silica gel, through silica gel column chromatography, using sherwood oil / ethyl acetate as eluent, the ratio of eluent is sherwood oil / acetone from 20:1,10:1,5: 1,3:1 to obtain the compound of the present invention.

[0020] The sesquiterpene represented by the structural formula (I) is a colorless crystal or an amorphous powder, and the molecular formula is C 15 h 20 o 2 , and its NMR data are as follows:

[0021] The NMR data of the compound (inCDCl 3 ) (δ, ppm)

[0022]

[0023]

[0024] The sesquiterpene represented by the structural formula (I) is a colorless crystal or an amorphous powder, and the molecular formula is C 15 h 20 o 2 ,...

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PUM

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Abstract

The invention discloses a sesquiterpene and a preparation method and use of the sesquiterpene as an antitumor drug. The preparation method comprises the following steps: by taking dicotyledoneae asterales compositae eupatorium crofton weed all grass as a raw material, extracting by ethyl acetate; after concentration, carrying out silica gel column chromatography; determining the compound which is a novel sesquiterpene Eupatorium adenophorum B through detection by hydrogen spectrum and carbon spectrum of nuclear magnetic resonance as well as X-single crystal diffraction. Cell experiments show that the novel compound has a certain inhibiting effect to human lung cancer cells A549 and H1299 and human cervical carcinoma cell HeLa.

Description

technical field [0001] The invention relates to the field of chemical separation of natural medicines, in particular to a novel sesquiterpene isolated from the whole herb of the genus Eupatorium adenophorum of the genus Asteraceae of the family Asteraceae and the specific preparation method and application thereof. Background technique [0002] Eupatorium adenophorum (Eupatorium adenophorum Spreng) is distributed in Yunnan, Guizhou, Sichuan, Guangxi, Tibet and other places in my country. Eupatorium adenophorum has strong vitality, wide adaptability and strong allelopathic effect, and it is easy to become the dominant species in the community , and even develop into a single dominant community, known as malignant weeds. However, pharmacological studies have shown that Eupatorium adenophorum has certain physiological activities. Zhao Ping from Yunnan Agricultural University found that the soaking solution of Eupatorium adenophorum had a killing effect on snails; Chen Xiaojuan ...

Claims

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Application Information

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IPC IPC(8): C07C49/653C07C45/79A61K31/122A61P35/00
CPCC07B2200/13C07C45/78C07C49/653C07C2603/66
Inventor 陈封政熊俊如李书华
Owner 成都格纯生物医药有限公司
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