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Application of fucoidan in the preparation of drugs for treating cachexia and cancer

A technology for fucoidan and cachexia, which is applied to fucoidan to improve or slow down the symptoms of cachexia, and the application field of fucoidan in the preparation of a medicine for treating bladder cancer

Active Publication Date: 2016-09-28
HI Q MARINE BIOTECH INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no prior art revealing that fucoidan can be used to treat cachexia

Method used

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  • Application of fucoidan in the preparation of drugs for treating cachexia and cancer
  • Application of fucoidan in the preparation of drugs for treating cachexia and cancer
  • Application of fucoidan in the preparation of drugs for treating cachexia and cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Example 1 Application of fucoidan in the treatment of cachexia and cancer

[0046] 1. Materials and methods

[0047] 1.1 Fucoidan

[0048] Fucoidan is extracted from Taiwan brown algae. It is first treated with hot water and then digested with enzymes to obtain fucoidan with a molecular weight of 500 Da or lower. The concentrations used in cell line experiments are 25, 50, and 100 μg / ml, and the doses used in animal experiments are 80, 160, and 300 mg / kg per day.

[0049] 1.2 Cell culture

[0050] Bladder cancer cell T24 was purchased from the National Cell Bank, derived from human female bladder transitional epithelial cell carcinoma, and its growth characteristics were adherent monolayer cells. T24 cells were cultured in 10% fetal bovine serum (FBS), 0.2% NaHCO 3 , 100u / ml penicillin (Penicillin), 100μg / ml streptomycin (Streptomycin) RPMI1640 complete culture solution. Cultured in a 37°C incubator containing 5% CO2 and saturated water vapor, the culture medium wa...

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Abstract

The invention discloses the application of fucoidan in the preparation of drugs for treating cachexia and cancer. The cachexia may be caused by a disease, condition or injury selected from the group consisting of cancer, immunodeficiency disease, infectious disease, autoimmune disease, metabolic disease, and chronic bowel, liver, kidney, lung and Heart disease, anorexia, trauma, burns, malabsorption and anemia. In one embodiment, the medicament of the present invention can be administered to a patient suffering from a disease that may produce cachexia, eg, cancer and the like. In particular, the present invention also provides the application of fucoidan in the preparation of drugs for treating bladder cancer, especially the application in inhibiting bladder cancer tumor growth, tumor angiogenesis, cancer cell migration and invasion.

Description

technical field [0001] The present invention relates to a novel therapy and pharmaceutical composition for cachexia and cancer. Specifically, the present invention provides a method for using fucoidan to improve or alleviate symptoms of cachexia in individuals in need, such as cancer patients. The present invention also relates to the application of fucoidan in the preparation of medicines for treating bladder cancer, especially the ability to inhibit tumor growth, tumor angiogenesis, cancer cell migration and invasion of bladder cancer. Background technique [0002] Cachexia (cachexia) is a complex metabolic syndrome produced under disease conditions. The main clinical symptoms are muscle wasting and weight loss (Evans WJ et al. Clin Nutr. 2008;27:793). The current clinical criteria for diagnosing cachexia are: the patient has sustained weight loss, for example, a weight loss of 5% of the original body weight within one year, accompanied by three of the following five crit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K45/00A61P35/00A61P1/14A61P21/00A61P29/00
Inventor 赖媛淑
Owner HI Q MARINE BIOTECH INT
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