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Method for establishing large animal liver damage model

A technology of injury model and establishment method, which is applied in the medical field, can solve the problems of high animal mortality and injury, and achieve the effect of low mortality and shortening time

Inactive Publication Date: 2014-11-05
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for establishing a large animal liver injury model, which solves the problems of high animal mortality and toxic drugs causing damage to other organs of animal individuals while producing an acute liver injury model in the prior art

Method used

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  • Method for establishing large animal liver damage model
  • Method for establishing large animal liver damage model

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Embodiment Construction

[0015] The present invention will be described in detail below in combination with specific embodiments.

[0016] The invention includes establishment of chronic liver pathological model and establishment of acute liver injury model.

[0017] 1. Establishment of chronic liver pathological model: anesthetize large animals (large animals such as rhesus monkeys or pigs), open the abdomen and place a "portal venous pump" in the mesenteric vein, and fix it under the skin of the abdomen. After that, the "portal venous pump" can be used repeatedly. , Injecting liver toxic drugs to animals many times, creating animal liver injury models, and providing animal liver pathological models for scientific research and drug research. The "portal venous pump" uses an existing subcutaneous venous pump. Such as figure 1 Subcutaneous implantable infusion set shown, figure 2 It is a schematic diagram of perfusing liver injury medicine through portal vein pump of the present invention. Since t...

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Abstract

The invention discloses a method for establishing a large animal liver damage model, wherein a chronic liver pathology model is established. The method includes the following steps of firstly, anesthetizing a large animal; secondly, opening the abdomen, reversing a portal vein venous pump at the mesenteric vein, and fixing the portal vein venous pump below the skin of the abdomen; thirdly, repeatedly injecting liver toxicity medicine into the animal multiple times through the portal vein venous pump. The medicine directly acts on the liver, and therefore the time for establishing the animal model can be shortened. When an acute liver damage model is established, the large animal is anesthetized; the abdomen is opened, and the proper hepatic artery is ligatured. The method has the advantages that when the acute liver damage model is manufactured, the death rate of the animal is low; in addition, no toxic medicine causes toxicity vice-damage to other organs of the animal.

Description

technical field [0001] The invention belongs to the field of medical technology and relates to a method for establishing a large animal liver injury model. Background technique [0002] Liver injury is the result of various liver diseases, and the prevention and treatment of liver injury is still a serious issue. It is of great practical significance to establish experimental liver injury animal models to study the mechanism of liver disease, screen hepatoprotective drugs, and explore the principle of hepatoprotective action. This paper summarizes and discusses the research progress of animal models of experimental liver injury in recent years, such as classification, mechanism of action, modeling methods and their advantages and disadvantages. Contents of the invention [0003] The purpose of the present invention is to provide a method for establishing a large animal liver injury model, which solves the problems of high animal mortality and toxic drugs causing damage to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/00
Inventor 王峻峰孙志为司维袁红伶唐建中李星逾董坤徐敬胡辉孟春城李波
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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