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A method for extracting sea papaverine from bundled fairy rope

A technology for sea papaverine and tying immortal rope, which is applied in the field of sea papaverine extraction, and achieves the effects of cost saving, easy operation for inspection and identification of slabs, and simple and easy method.

Active Publication Date: 2016-03-30
XI AN JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the domestic and foreign researches on the binding fairy rope are limited to the reports of Japanese scholar Toru Kikuchi and Professor Duan Hongquan of my country in the 1960s and 1980s on the chemical composition of the steroidal alkaloids of the plant. No other structural types of alkaloids have been seen Report on extraction and separation methods

Method used

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  • A method for extracting sea papaverine from bundled fairy rope
  • A method for extracting sea papaverine from bundled fairy rope
  • A method for extracting sea papaverine from bundled fairy rope

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The method for extracting sea papaverine from bundle fairy rope, comprises the following steps:

[0032] 1) Take about 7.5kg of the bundled fairy rope coarse powder, and extract it with 95% ethanol for 3 times under reflux, each time for 2 hours, recover the extract, concentrate under reduced pressure to obtain the extract, and use 10L of 1.0kg extract with a mass concentration of 2% The hydrochloric acid is dissolved and then filtered, and the filtrate is passed through the LS-12 strongly acidic macroporous styrene cation exchange resin at a flow rate of 1BV / h, and washed with water until the effluent is neutral. Take out the resin and soak 12 hours in ammonia water with 4 times the volume of the resin mass and a mass concentration of 10%, add 95% ethanol with 8 times the volume of the resin mass to the obtained alkalized resin and reflux for 1.5 hours, reclaim the solvent, and obtain the fairy rope Total alkaloid extract 61.8g.

[0033] 2) Take 50.0g of the total alk...

Embodiment 2

[0046] The method for extracting sea papaverine from bundle fairy rope, comprises the following steps:

[0047] 1) Take about 7.5kg of the bundled fairy rope coarse powder, extract twice with 95% ethanol under reflux, each time for 3 hours, recover the extract, concentrate under reduced pressure to obtain the extract, and use 8L of the extract for 1.0kg with a mass concentration of 1.5% The hydrochloric acid is dissolved and filtered, and the filtrate is passed through LS-12 strongly acidic macroporous styrene cation exchange resin at a flow rate of 0.5BV / h, and washed with water until the effluent is neutral. Take out the resin and soak 10 hours in ammonia water with 3 times the volume of the resin quality and a mass concentration of 15%, add 95% ethanol with 8 times the volume of the resin quality to the obtained alkalized resin and reflux for 1.5 hours, reclaim the solvent, and obtain the fairy rope Total alkaloid extract 60.9g.

[0048] 2) Take 50.0g of the total alkaloid...

Embodiment 3

[0052] The method for extracting sea papaverine from bundle fairy rope, comprises the following steps:

[0053] 1) Take about 7.5kg of the bundled fairy rope coarse powder, extract it with 95% ethanol for 4 times, each time for 2 hours, recover the extract, concentrate under reduced pressure to obtain the extract, use 12L of 1.0kg extract with a mass concentration of 1% The hydrochloric acid is dissolved and then filtered, and the filtrate is passed through LS-12 strongly acidic macroporous styrene cation exchange resin at a flow rate of 1.5BV / h, and washed with water until the effluent is neutral. Take out the resin and soak 14 hours in ammonia water with 4 times the volume of the resin quality and a mass concentration of 8%, add 95% ethanol with 8 times the volume of the resin quality to the obtained alkalized resin and reflux for 1.5 hours, reclaim the solvent, and obtain the fairy rope Total alkaloid extract 60.2g.

[0054] 2) Take 50.0g of the total alkaloid extract of t...

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Abstract

The invention discloses a method for extracting glaucine from pachysandra terminalis Sieb.et Zucc., and belongs to the technical field of extraction of natural products. The method comprises the following steps: 1) getting a pachysandra terminalis Sieb.et Zucc. total alkaloids extractum, applying to an alkaline silica gel column, taking a chloroform-methanol system as an eluent for gradient elution, merging fractions and distilling off the solvent, so as to obtain a first column-chromatograph substance; 2) applying the first column-chromatograph substance to a silica gel column, taking a chloroform-methanol system as an eluent for gradient elution, merging fractions with a same main spot, and distilling off the solvent, so as to obtain a second column-chromatograph substance; 3) applying the second column-chromatograph substance to a dextran gel column, taking a chloroform-methanol system as an eluent for gradient elution, merging fractions with a same main spot, and distilling off the solvent, so as to obtain a third column-chromatograph substance; and 4) repeatedly washing the third column-chromatograph substance with methanol, so as to obtain glaucine. The method is simple in operation, low in cost and high in extraction efficiency, and the obtained glaucine has the purity of 99% or more.

Description

technical field [0001] The invention belongs to the technical field of natural product extraction, and in particular relates to a method for extracting sea papaverine from bundled fairy ropes. Background technique [0002] The folk medicine bundle fairy rope is the whole plant of Pachysandra terminalis Sieb. et Zucc. of the genus Pachysandra terminalis Sieb. et Zucc. The top flower bench fruit is also known as the top pistil triangular rice, the evergreen grass, the bundled fairy seven, the tendon grass, and the rich grass. Because the main component of this plant is alkaloids, it has the effects of dispelling rheumatism, promoting blood circulation and relieving pain. Therefore, Shaanxi folks are mainly used to treat rheumatic paralysis, numbness of limbs, bruises, menorrhagia, and restlessness. So far, the domestic and foreign researches on the binding fairy rope are limited to the reports of Japanese scholar Toru Kikuchi and Professor Duan Hongquan of my country in the 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D221/18
CPCC07D221/18
Inventor 郭增军李梦怡肖勋霞张卉席可薛璇玑
Owner XI AN JIAOTONG UNIV
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