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Ilex kudingcha C. J. Tseng extract

A technology of kudingcha holly and extract, which is applied in the direction of testing pharmaceutical preparations, material inspection products, etc., and can solve problems such as unclear toxic components

Active Publication Date: 2015-02-25
杭州陶朱公生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports about the structure and pharmacological activity of the phenolic components of the plant, and the toxic components of the plant are also unclear

Method used

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  • Ilex kudingcha C. J. Tseng extract
  • Ilex kudingcha C. J. Tseng extract
  • Ilex kudingcha C. J. Tseng extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Preparation of total phenolic acids of Kudingcha Dongqing

[0064] Take 1 kg of holly leaves of Kudingcha, grind them into coarse powder, add 95% alcohol to reflux and extract for 3 times, combine the extracts, concentrate under reduced pressure, and obtain 280 g of alcoholic extract. Stir and dissolve the extract with 1.5L purified water, add dilute sodium hydroxide dropwise to adjust the pH value to about 7, centrifuge, filter, acidify the filtrate to pH 2 with 5% hydrochloric acid, let stand for 2 hours, filter, wash the precipitate with water until the effluent The pH was about 5, and it was drained to obtain about 128g of precipitate. Add the filtrate to a polyamide (30-60 mesh) adsorption column, and elute with water first. When the color of the effluent becomes lighter and the acidity drops to about pH 5, use 80% alcohol for eluting, and collect the alcohol eluate. Concentrate under reduced pressure to obtain about 12 g of paste, which is incorpora...

Embodiment 2

[0065] Take 1 kg of holly leaves of Kudingcha, crush them into coarse powder, add water to decoct 3 times, combine the extracts, concentrate under reduced pressure to obtain 220 g of extract. Stir and dissolve the extract with 1.5L water, add 5% sodium carbonate to adjust the pH to about 7, centrifuge, filter, acidify the filtrate to pH 2 with 5% sulfuric acid, let it stand for 2 hours, filter, wash the precipitate with water until the effluent pH is about 5, Dried up, about 100 g of precipitate was obtained. Add the filtrate to a polyamide (30-60 mesh) adsorption column, elute with water first, until the color of the effluent becomes lighter and the acidity drops to about pH5, use 60% alcohol for eluting, collect the alcohol eluate, reduce Concentrate under reduced pressure to obtain about 10 g of a paste, which is incorporated into the precipitated part. After the precipitate was dried, reflux with hexane to degrease 3 times, filter, evaporate to dryness, and then reflux wi...

Embodiment 3

[0066] Example 3: Preparation of Kudingcha Dongqing Total Phenolic Acid

[0067] Get the total phenolic acid 20g that embodiment 1 or 2 gained, slowly add 5% sodium hydroxide appropriate amount in batches, make fully dissolving under stirring, control solution pH7~8, filter, spray dry, obtain total phenolic acid salt 19g. This product has good water solubility and can be used as a raw material for various solid and liquid preparations.

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Abstract

The invention relates to Ilex kudingcha C. J. Tseng leaf extract with a medical value and a preparation method thereof. The extract is characterized in that the Ilex kudingcha C. J. Tseng leaf extract is enriched with caffeoylquinic acid effective components; a toxic component, namely Ilex kudingcha C. J. Tseng cyanogenic glycoside and a bitter substance are removed; and the Ilex kudingcha C. J. Tseng extract leaf extract has the activities of resisting oxidization, lowering blood lipid, resisting viruses and the like, and can be used for producing medicines or health products for preventing and treating cardiovascular and cerebrovascular diseases, hyperlipemia symptoms and virus hepatitis.

Description

technical field [0001] The present invention is a divisional application of patent application No. 201110162622.0. The invention name of the original patent application No. 201110162622.0 is: a Kudingcha holly extract, and the filing date is: June 16, 2011. The invention belongs to the field of medicinal plant extracts, and relates to a kudingcha holly extract and a preparation method thereof and its application in the preparation method, including removing toxic components kudingcha cyanoside and bitter quality. Background technique [0002] Kudingcha holly (Ilex kudingcha C.J.Tseng) is an arbor plant of the family Ilex, and is one of the varieties of Kudingcha commonly used in southern my country. There is a record of this product in reducing fat in the ancient book "Supplements to Materia Medica": "Long-term food makes people thin , to remove human fat". In the past 30 years, many scholars have conducted research on this plant (Research and Development of Natural Products...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15
Inventor 李素珍
Owner 杭州陶朱公生物科技有限公司
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