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Preparation method of nine flavor swertia bimaculata tablet and application of nine flavor swertia bimaculata tablet in preparation of drugs for inhibition of cell proliferation of myeloma cell SP2/0

A technology of Jiuwei Swertia Swertia Tablets and Swertia Swertia, which is applied in drug delivery, drug combination, anti-tumor drugs, etc., and can solve the problems of many impurities, backwardness, and impact on clinical application.

Inactive Publication Date: 2015-03-11
SHANDONG ZHONGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no Jiuwei Swertia Capsules that use CO in the extraction and preparation 2 There are reports of supercritical extraction, microwave technology and macroporous resin adsorption technology for extraction, while the method of directly powdering traditional Chinese medicine is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 53.6g Swertia, 17.9g Golden Yeast, 35.7g Bangga, 35.7g Muxiang, 35.7g Lago-ear Grass, 42.9g Sorbet, 35.7g Horn Fennel, Barberry Bark 28.6g, and Melon Seed 14.2 g: Take wood incense and fennel, crush into fine powder, add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 5% of the total extraction solvent, the extraction pressure is 25MPa, the temperature is 40°C, and CO 2 Flow rate 2ml / g crude drug·min, extraction time 150min, get supercritical extract, ready for use; extract woody, fennel residue and other seven medicinal materials, crush, add 2L of 60% ethanol, and put into microwave extraction device for microwave Extraction, extraction power 700W, extraction 2 times, 8 minutes each time, combine the extracts, concentrate, add to Diaion HP-10 macroporous adsorption resin column, elute with 60% ethanol, collect 5 times the column volume eluent, The ethanol was recovered under reduced pressure, concentrated and drie...

Embodiment 2

[0034] Take 53.6g Swertia, 17.9g Golden Yeast, 35.7g Bangga, 35.7g Muxiang, 35.7g Lago-ear Grass, 42.9g Sorbet, 35.7g Horn Fennel, Barberry Bark 28.6g, and Melon Seed 14.2 g: Take wood incense and fennel, crush into fine powder, add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%. The extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 130min, and the supercritical extract is obtained for use; the extracted woody, fennel residue and other seven medicinal materials are crushed, and 2L of 60% ethanol is added to the microwave extraction device for microwave Extraction, extraction power 600W, extraction 2 times, 8 minutes each time, combine the extracts, concentrate, add to Diaion HP-10 macroporous adsorption resin column, 60% ethanol elution, collect 5 times the column volume eluate, The ethanol was rec...

Embodiment 3

[0037] Take 53.6g Swertia, 17.9g Golden Yeast, 35.7g Bangga, 35.7g Muxiang, 35.7g Lago-ear Grass, 42.9g Sorbet, 35.7g Horn Fennel, Barberry Bark 28.6g, and Melon Seed 14.2 g: Take wood incense and fennel, crush into fine powder, add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 6% of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 30°C, and CO 2 Flow rate 1ml / g crude drug·min, extraction time 170min, get supercritical extract, ready for use; extract woody, fennel residue and other seven medicinal materials, crush, add 2L of 60% ethanol, put it into the microwave extraction device for microwave Extraction, extraction power 800W, extraction 2 times, 10 minutes each time, combine the extracts, concentrate, add to Diaion HP-10 macroporous adsorption resin column, 60% ethanol elution, collect 5 times the column volume eluate, The ethanol was recovered under reduced pressure, concentrated and dri...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method and application of a nine flavor swertia bimaculata tablet. The nine flavor swertia bimaculata tablet is prepared from 53.6g of swertia bimaculata, 17.9g of chrysosplenium, 35.7g of herba aconiti, 35.7g of radix aucklandiae, 35.7g of lagotis brevituba maxim, 42.9g of indian lettuce, 35.7g of hypecoum erectum, 28.6g of cortex berberidis and 14.2g of herpetospermum seed as raw material medicines by supercritical fluid extraction, microwave extraction and macroporous resin adsorption, and the content of berberine hydrochloride is greatly improved. The invention also provides application of the nine flavor swertia bimaculata tablet in preparation of drugs for inhibition of cell proliferation of myeloma cell SP2 / 0 in mice.

Description

Technical field [0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a preparation method of Jiuwei zhangjiacai tablets and its application in preparing drugs for inhibiting the proliferation of mouse myeloma cells SP2 / 0. Background technique [0002] The standard number of Jiuwei Zhangyacai Capsules is WS-11182 (ZD-1182)-2002, which is recorded in the Internal Medicine Hepatobiliary Division of the National Compilation of Chinese Patent Medicine Standards. 53.6g Swertia Swertia, 17.9g Golden Yeast, 35.7g Bangga, 35.7g Woody, 35.7g Lago-ear Grass, 42.9g Sorbet, 35.7g Horn Fennel, Barberry Bark 28.6g, Melon Seed 14.2 g is made as a raw material medicine, which has the effects of clearing heat, reducing inflammation and relieving pain. For cholecystitis, acute jaundice hepatitis. [0003] In the prior art, there is no Jiuwei Swertia Capsules that use CO in extraction and preparation. 2 Supercritical extraction, mic...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/20A61P35/00
CPCA61K36/185A61K9/0053A61K9/20A61K36/28A61K36/285A61K36/29A61K36/42A61K36/51A61K36/66A61K36/714A61K36/898A61K2236/15A61K2236/33A61K2236/37A61K2236/51A61K2236/55A61K2300/00
Inventor 权栋栋朱立平陈云李加美王丽丽
Owner SHANDONG ZHONGDA PHARMA
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