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A kind of preparation method of nanocomposite antibacterial dressing

A nano-composite, antibacterial technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of easy agglomeration, large R&D investment, and high operation requirements, and achieve super adsorption capacity, low manufacturing cost, and large specific surface area. Effect

Inactive Publication Date: 2016-04-20
重庆辽远医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Organic antibacterial technology: It has the advantages of strong initial sterilizing power, fast sterilizing speed, and wide antibacterial range, but has defects such as poor heat resistance, washing resistance, short service life, etc., and has certain toxicity
[0006] 2. Inorganic antibacterial technology: mainly silver-based antibacterial agents, which are characterized by not easy to seep out, good heat resistance and durability, but its disadvantages are high price, slow antibacterial effect, not resistant to washing, and antifungal Poor, at the same time, the compatibility between inorganic antibacterial powder and polymer material is poor, and it is easy to agglomerate in the matrix resin, which brings difficulties to material spinning and film drawing;
However, the R&D investment of this technology is large, the specific implementation process is complicated, and the operation requirements are high, which is suitable for a large number of large-scale production needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of nanocomposite antibacterial agent: silicon dioxide, titanium dioxide, zinc oxide, and magnesium oxide are dissolved in deionized water in a molar ratio of 40:20:15:25, and the concentration is prepared into a 5% aqueous solution; Add 0.5% cetyltrimethylammonium bromide as a surfactant and 1% Tween 20 as an emulsifier; transfer the solution to a three-necked flask, and stir for 2 hours at a temperature of T=40°C to obtain a uniform antibacterial agent dispersion;

[0030] (2) Preparation of polymer solution: directly dissolve the water-soluble polymer polyoxyethylene in deionized water, prepare an aqueous solution with a concentration of 3%, stir magnetically for 24 hours, and obtain a uniform polymer solution;

[0031] (3) Preparation of composite antibacterial dressing: Mix the polymer solution and the nanocomposite antibacterial agent at a mass ratio of 8:2, mechanically stir for 12 hours, and leave the solution ultrasonically to remove air bubbles ...

Embodiment 2

[0033] (1) Preparation of nano-composite antibacterial agent: silicon dioxide, titanium dioxide, zinc oxide, and magnesium oxide are dissolved in deionized water in a molar ratio of 40:20:15:25, and are mixed with an 8% aqueous solution; Add 0.5% cetyltrimethylammonium bromide as a surfactant and 1% Tween 20 as an emulsifier; transfer the solution to a three-necked flask, and stir for 2 hours at a temperature of T=40°C to obtain a uniform antibacterial agent dispersion;

[0034] (2) Preparation of polymer solution: directly dissolve the water-soluble polymer polyoxyethylene in deionized water, prepare an aqueous solution with a concentration of 3%, stir magnetically for 24 hours, and obtain a uniform polymer solution;

[0035] (3) Preparation of composite antibacterial dressing: Mix the polymer solution and the nanocomposite antibacterial agent at a mass ratio of 8:2, mechanically stir for 12 hours, and leave the solution ultrasonically to remove air bubbles in the solution; ...

Embodiment 3

[0037] (1) Preparation of nano-composite antibacterial agent: silicon dioxide, titanium dioxide, zinc oxide, and magnesium oxide are dissolved in deionized water in a molar ratio of 40:20:15:25, and are mixed with an 8% aqueous solution; Add 0.5% cetyltrimethylammonium bromide as a surfactant and 1.5% Tween 20 as an emulsifier; transfer the solution to a three-necked flask and stir for 2 hours at a temperature of T=60°C to obtain a uniform antibacterial agent dispersion;

[0038] (2) Preparation of polymer solution: directly dissolve the water-soluble polymer polyoxyethylene in deionized water, prepare an aqueous solution with a concentration of 3%, stir magnetically for 24 hours, and obtain a uniform polymer solution;

[0039] (3) Preparation of composite antibacterial dressing: Mix the polymer solution and the nanocomposite antibacterial agent at a mass ratio of 8:2, mechanically stir for 12 hours, and leave the solution ultrasonically to remove air bubbles in the solution; ...

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Abstract

The invention provides a method for preparing a nano-compound antibacterial dressing. The antibacterial dressing is prepared by the following steps: preparing the following raw materials in a certain percentage: various precursors having different nano-scales, an emulsifier and surfactant, and stirring for 2-3 hours at a temperature T being 40-60 DEG C to obtain a dispersion of an antibacterial agent; adding the dispersion of the antibacterial agent into a water-soluble polymer solution with a certain concentration, and mechanically stirring for 12 hours to obtain a uniform solution; and freeze-drying the polymer solution to obtain the nano-compound antibacterial dressing. The nano-compound antibacterial dressing prepared by the method is wide in raw material source, low in cost, good in air permeability and remarkable in antibacterial and anti-ultraviolet effect.

Description

technical field [0001] The invention discloses a preparation method of a nanocomposite antibacterial dressing, which belongs to the field of preparation of biomedical dressings. Background technique [0002] The skin is an important organ of the human body, a natural barrier and a bridge of communication between the body and the outside world. Loss of skin tissue due to burns, trauma, and skin ulcers can lead to wound infection. Currently, one effective method of dealing with skin wounds is the use of wound dressings. [0003] Traditional wound dressings include gauze, absorbent cotton, bandages, etc. However, from a medical point of view, these traditional wound dressings have limited clinical application because they do not have the properties of treating and repairing wounds, nor do they have antibacterial activity. Therefore, new medical dressings that can promote wound healing, have high antibacterial properties and are more convenient to use have gradually developed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/18A61L15/24A61L15/26
Inventor 徐再赵云龙徐靖
Owner 重庆辽远医药科技有限公司
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