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The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn

A technology of unicorn and compound, which is applied in the field of natural product extraction, can solve the problems of lack of basic research on activity and medicinal substances, and achieve the effect of improving medicinal value, simplifying the extraction process, and avoiding damage

Active Publication Date: 2016-01-13
东营悦来湖园区运营管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To sum up, Bijiaoxian has a long history and rich resources as a traditional Chinese medicine in my country; on the other hand, its activity and basic research on medicinal substances are still very scarce

Method used

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  • The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn
  • The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn
  • The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn

Examples

Experimental program
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Effect test

Embodiment 1

[0063] The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn, comprising the following steps:

[0064] Step 1. Take 1000g of the imago imago, wash it with clear water and dry it in the air, then place it in an oven at 30°C and dry it to constant weight, take it out and pulverize it to obtain the imago unicorn powder, and set aside; Under the condition of ℃, soak 40h with the dichloromethane of 5 times of the weight of the unicorn powder, use ultrasonic wave to assist extraction in the immersion process, filter, add the dichloromethane of 5 times of the weight of the unicorn powder to the obtained filter residue again, at 22 Soak for 40 hours under the condition of ℃, use ultrasonic to assist extraction during the soaking process, filter after the extraction is completed, place the obtained filter residue in a ventilated place and air-dry at room temperature to obtain insect residue, and set aside;

[0065] Step 2. Add methanol solution ...

Embodiment 2

[0072] The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn, comprising the following steps:

[0073] Step 1. Take 1500g of the adult unicorn, wash it with clear water, and dry it in the air, then place it in an oven at 50°C and dry it to constant weight, take it out and pulverize it to obtain the unicorn powder, and set aside; put the unicorn powder at 24 Under the condition of ℃, soak 44h with dichloromethane of 10 times the weight of unicorn powder, use ultrasonic wave to assist extraction in the soaking process, filter, and add 10 times of the weight of unicorn powder to the obtained filter residue in dichloromethane again, at 24 Soak for 44 hours under the condition of ℃, use ultrasonic wave to assist extraction during the soaking process, filter after the extraction is completed, and place the obtained filter residue in a ventilated place to air dry at room temperature to obtain worm residue for later use;

[0074] Step 2. Add me...

Embodiment 3

[0081] The method for extracting norcanone derivatives and purine alkaloid compounds from the unicorn, comprising the following steps:

[0082] Step 1. Take 2500g of the imago unicorn, wash it with clear water, and dry it in the air, then place it in an oven at 65°C and dry it to constant weight, take it out and crush it to obtain the unicorn powder, and set aside; put the unicorn powder at 26 Under the condition of ℃, soak 48h with the dichloromethane of 15 times of the weight of the unicorn powder, and use ultrasonic wave to assist extraction in the soaking process, filter, add the dichloromethane of 15 times of the weight of the unicorn powder to the obtained filter residue again, at 26 Soak for 48 hours under the condition of ℃, use ultrasonic wave to assist extraction during the soaking process, filter after the extraction is completed, and place the obtained filter residue in a ventilated place to dry at room temperature to obtain insect residue, which is ready for use; ...

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Abstract

The invention discloses a method for extracting norcanone derivatives and purine alkaloids from the unicorn fairy, which comprises the following steps: step 1, soaking the unicorn powder with dichloromethane, and filtering to obtain worm residue; step 2 1. Adding mass percent to the worm residue is 70% methanol solution for extraction, concentrating, freezing the concentrated solution into ice, and drying to obtain the extract of the unicorn fairy; step 3, the 70% methanol solution for the extraction of the unicorn fairy extract, Silica gel column elution, combining similar fractions; step 4, separating the sixth fraction by gel column chromatography to obtain compound I; step 5, combining fractions 11 and 12, and separating by polyamide column chromatography; The third fraction was recrystallized to give compound II; the fourth fraction was recrystallized to give compound III. The present invention extracts and separates three compounds for the first time from the unicorn, which are respectively identified as a new norcanone derivative and two new purine alkaloid compounds.

Description

Technical field [0001] The invention is a natural product extraction technology field, mainly involving a method of extracting ketone derivatives and purine alkali compounds from unicorn. Background technique [0002] Due to rich resources and strong activity, medicinal insects have great potential in the development of new drugs.The unicorn fairy ALLOMYRINADICHOTOMA (Linnaeus), also known as the double fork rhinoplasty turtle, is an insect meal-cypress-golden turtle beetle.There are currently about 60 unicorns with large -scale horn in the world, and there are more than 1,300 other types of small or not obvious types.Traditional Chinese medicine is also called unicorn insects.Unicorn has high medicinal value.Chinese medicine is used for medicine, captured in summer, and dried or dried for later use after boiling water.Modern pharmaceutical research has found that the animal insects of the limbs also have the effects of treating leukemia and anti -cancer.For example, in 1976, it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/74C07C67/48C07D473/34C07C67/56
CPCC07C67/48C07C67/52C07C67/56C07C67/58C07C2601/18C07D473/34C07C69/74
Inventor 尹卫平牛兰岚刘军娜高嘉屿李海迪刘华清李文亮
Owner 东营悦来湖园区运营管理有限公司