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Ribavirin oral liquid and preparation method thereof

A technology of virin oral liquid and ribavirin, applied in the field of ribavirin oral liquid, can solve the problems of unfavorable long-term storage, low stability, etc., and achieve a wide range of applications, ensure product safety, and increase sweetness. Effect

Active Publication Date: 2018-01-02
常州康普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention overcomes the disadvantages of low stability of ribavirin oral liquid preparations in the prior art and is unfavorable for long-term storage, and provides a ribavirin oral liquid and a preparation method thereof

Method used

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  • Ribavirin oral liquid and preparation method thereof
  • Ribavirin oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Table 1 Components and content

[0016] Raw materials

Example 1

Example 2

Example 3

Example 4

Example 5

Ribavirin (g)

3.00

3.00

3.00

3.00

3.00

Xylitol (g)

3

3

3.5

3

4

Disodium hydrogen phosphate (g)

0.267

0.8

0.4

0.534

0.6

Menthol (g)

1

0.5

0.7

0.5

0.80

Activated carbon (g)

0.2

0.1

0.05

0.1

0.2

Propylene glycol (ml)

1

0.5

0.7

0.8

0.8

Water for injection (ml)

Add to 100ml

Add to 100ml

Add to 100ml

Add to 100ml

Add to 100ml

Taste (sweetness)

sweetness

sweetness

sweet

sweet

sweet

pH value

5.5

6.0

5.7

5.6

5.8

[0017] Such as figure 1 Shown, the preparation method of above-mentioned ribavirin oral liquid, the steps are as follows: add the water for injection of preparation total amount 80% in the preparation tank, add successively xylito...

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Abstract

The invention belongs to the field of medicines, in particular to ribavirin oral liquid. The invention overcomes the disadvantages of low stability of the ribavirin oral liquid preparation in the prior art and is unfavorable for long-term storage, and provides a ribavirin oral liquid and a preparation method thereof. In order to solve the above-mentioned technical problems, the technical scheme adopted in the present invention is: a kind of ribavirin oral liquid, its every thousand oral liquid is 5000ml, contains ribavirin 0.15kg, xylitol 0.15~0.2kg, Disodium hydrogen phosphate 13.35-40g, menthol 25g-50g, activated carbon 2.5-10g, propylene glycol 25-50ml, and the balance is water for injection. The beneficial effect of the invention is that the pH content and storage period related substances (impurities) do not increase, ensuring product safety.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to ribavirin oral liquid. Background technique [0002] Ribavirin, also known as ribavirin and ribavirin, is a broad-spectrum antiviral drug. It has the effect of inhibiting respiratory syncytial virus, influenza virus, adenovirus and other viruses. It is suitable for viral pneumonia and bronchitis caused by respiratory syncytial virus, skin herpes virus infection, etc. [0003] Ribavirin medicine can be made into various preparation forms, such as injection, tablet, oral liquid and so on. When used as an oral liquid preparation, it is often unfavorable for preservation due to its low stability. After a long period of storage, it will lead to the decomposition and failure of the effective substance for drug degradation, resulting in the failure of the drug action, thereby losing the therapeutic effect. There is still no effective solution to its stability in the prior art. Contents of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7056A61K47/10A61P31/14A61P31/16A61P11/00A61P31/22A61P17/00
Inventor 王苏南汤金春
Owner 常州康普药业有限公司
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