Integration dysfunction syndrome marker set and utilization thereof

A technology of schizophrenia and markers, which is applied in the field of schizophrenia examination, and can solve problems such as unestablished and unclear physiology of the disease

Inactive Publication Date: 2015-06-10
NAGOYA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, the current situation is that the physiology of this disease is still unclear, and the diagnostic method based on biochemical examination has not yet been established.

Method used

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  • Integration dysfunction syndrome marker set and utilization thereof
  • Integration dysfunction syndrome marker set and utilization thereof
  • Integration dysfunction syndrome marker set and utilization thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0129] According to previous studies, 22 proteins whose correlation with schizophrenia were confirmed were identified (Patent Document 1). In order to identify a combination of biomarkers capable of high-precision discrimination, the following studies were conducted.

[0130] 1. Expression Analysis by Western Blot

[0131] (1) method

[0132] Take 30 schizophrenic patients (15 males: 43.7±12.6 years old, 15 females: 43.1±8.9 years old) and 30 healthy people (15 males: 44.4±12.9 years old, 15 females: 43.2±9.6 years old) As a target, the expression levels of the 22 identified proteins were reconfirmed by Western blotting.

[0133] (2) Results

[0134] Among the 22 proteins, 8 proteins were confirmed to have a significant difference in expression level (Student's t-test, pfigure 1 ).

[0135] 2. Make a disease discrimination model using statistical methods

[0136] Statistical hypothesis test was used to compare the mean difference of protein expression between the schizoph...

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Abstract

The present invention addresses the problem of providing a combination of biomarkers, whereby integration dysfunction syndrome can be highly accurately diagnosed, and the utilization thereof. Provided is an integration dysfunction syndrome marker set which comprises two or more protein molecules combined together, said protein molecules being selected from the group consisting of trifunctional purine biosynthetic protein adenosine-3, uroporphyrinogen decarboxylase, interferon-induced GTP-binding protein Mx1, glutaredoxin-3, microtubule-associated protein RP/EB family member 1, tubulin folding cofactor B, immunoglobulin mu chain C region and heat shock 70 kDa protein 4L. Also provided is a method for examining integration dysfunction syndrome with the use of the level of the aforesaid marker set in a specimen as an index.

Description

technical field [0001] The present invention relates to schizophrenia markers useful for examining schizophrenia. Specifically, it relates to a combination of biomarkers (biomarker set) that can be used to determine the likelihood (probability) of onset of schizophrenia, a test method for schizophrenia using the set of biomarkers, and the like. This application claims priority based on Japanese Patent Application No. 2012-228417 for which it applied on October 15, 2012, and uses all the content of this patent application by reference. Background technique [0002] Schizophrenia is a chronic and progressive mental illness with onset in adolescence and adolescence. It is characterized by positive symptoms (hallucinations, delusions, disordered speech or movement, etc.), Cognitive impairment (attention impairment, decreased working memory, executive dysfunction, etc.) is the main symptom. Schizophrenia is considered to be a multifactorial disease involving genetic factors and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53
CPCG01N33/6896G01N2800/60G01N2800/302G01N33/6893G01N2800/50
Inventor 尾崎纪夫永井拓吉见阳山田真之亮平川晃弘国本正子松本友里惠
Owner NAGOYA UNIVERSITY
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