Combination

A technology of compounds, drugs, applied in the field of combinations that can be used in this therapy, can solve problems such as uncontrolled cell proliferation

Inactive Publication Date: 2015-09-09
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, hyperactivation of this pathway causes uncontrolled cell proliferation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0228] Example 1 - Capsule Composition

[0229] Oral dosage forms for administering the combinations of the invention are prepared by filling standard two-part hard gelatin capsules with the ingredients in the proportions shown in Table I below.

[0230] Table I

[0231]

Embodiment 2

[0232] Example 2 - Capsule Composition

[0233] Oral dosage forms for administering one of the compounds of this invention are prepared by filling standard two-part hard gelatin capsules with the ingredients in the proportions shown in Table II below.

[0234] Table II

[0235]

Embodiment 3

[0236] Example 3 - Capsule Composition

[0237] Oral dosage forms for administering one of the compounds of this invention are prepared by filling standard two-part hard gelatin capsules with the ingredients in the proportions shown in Table III below.

[0238] Table III

[0239]

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Abstract

The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering -methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimi dazole-4-carboxylic acid, or a pharmaceutically acceptable salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.

Description

technical field [0001] The present invention relates to methods of treating cancer in mammals, and to combinations useful in such treatment. In particular, the approach involves novel combinations comprising the PI3K inhibitor: 2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4- Morpholinyl)-1H-benzimidazole-4-carboxylic acid or a pharmaceutically acceptable salt thereof, and a MEK inhibitor: N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo -phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidine-1- Base] phenyl} acetamide or a pharmaceutically acceptable salt or solvate thereof, to a pharmaceutical composition comprising the combination, and to a method of using the combination to treat cancer. Background technique [0002] Typically, cancers arise from dysregulation of the normal processes that control cell division, differentiation, and apoptosis. Apoptosis (programmed cell death) plays an important role in embryonic development and the pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K31/5377A61P35/00
CPCA61K31/519A61K31/5377A61P35/00A61P35/02A61K2300/00
Inventor K.E.巴克曼J.D.格雷肖克M.A.哈德威克
Owner GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD
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