A kind of intragastric ph detection micropill and its application

A technology of pellets and pellet cores, applied in the field of intragastric pH detection pellets, can solve the problems of intolerable repeated testing and unacceptable by patients, and achieve the effect of high clinical value, good patient tolerance, and low price

Inactive Publication Date: 2017-10-17
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method can accurately measure the pH value in the stomach, but it is an invasive test, which is often used for scientific research, and it is generally unacceptable for clinical outpatients, let alone repeated testing.

Method used

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  • A kind of intragastric ph detection micropill and its application
  • A kind of intragastric ph detection micropill and its application
  • A kind of intragastric ph detection micropill and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation and effect verification of intragastric pH detection pellets and capsules of the present invention (1)

[0025] 1. Preparation of pellets

[0026] 1. Materials

[0027] Eudragit L30D-55, purchased from Roehm, Germany;

[0028] Hydroxypropyl methylcellulose (HPMC), purchased from Ruitai Fine Chemical Co., Ltd., Feicheng, Shandong;

[0029] Triethyl citrate was purchased from Gaoshangmei Guangzhou Fine Chemical Co., Ltd.

[0030] 2. Method

[0031] 2.1 Preparation of Eudragit L30D-55 aqueous dispersion coating solution

[0032] Eudragit L30D-55 aqueous dispersion coating solution is composed of the following raw materials in weight percentage: Eudragit L30D-55 30%, triethyl citrate (TEC) 1%, micronized talc powder 4%, distilled water 65%.

[0033] Add triethyl citrate and talcum powder into water, and use a high-speed emulsifier to homogenize it. Stir before use and add to the Eudragit L30D-55 aqueous dispersion, filter through a 0.25mm sieve t...

Embodiment 2

[0051] Example 2 Preparation of intragastric pH detection pellets and capsules of the present invention (2)

[0052] 1. Preparation of pellets

[0053] 1. Materials

[0054] Eudragit L30D-55, purchased from Roehm, Germany;

[0055]Hydroxypropyl methylcellulose (HPMC), purchased from Ruitai Fine Chemical Co., Ltd., Feicheng, Shandong;

[0056] Triethyl citrate was purchased from Gaoshangmei Guangzhou Fine Chemical Co., Ltd.

[0057] 2. Method

[0058] 2.1 Preparation of Eudragit L30D-55 aqueous dispersion coating solution

[0059] Eudragit L30D-55 aqueous dispersion coating solution is composed of the following raw materials in weight percentage: Eudragit L30D-55 25%, triethyl citrate (TEC) 1.2%, micronized talc powder 3.5%, distilled water 70.3%.

[0060] Add triethyl citrate and talcum powder into water, and use a high-speed emulsifier to homogenize them. Stir before use and add to the Eudragit L30D-55 aqueous dispersion, filter through a 0.25mm sieve to obtain the Eudr...

Embodiment 3

[0065] Example 3 Preparation of intragastric pH detection pellets and capsules of the present invention (3)

[0066] 1. Preparation of pellets

[0067] 1. Materials

[0068] Eudragit L30D-55, purchased from Roehm, Germany;

[0069] Hydroxypropyl methylcellulose (HPMC), purchased from Ruitai Fine Chemical Co., Ltd., Feicheng, Shandong;

[0070] Triethyl citrate was purchased from Gaoshangmei Guangzhou Fine Chemical Co., Ltd.

[0071] 2. Method

[0072] 2.1 Preparation of Eudragit L30D-55 aqueous dispersion coating solution

[0073] Eudragit L30D-55 aqueous dispersion coating solution is composed of the following raw materials in weight percentage: Eudragit L30D-55 35%, triethyl citrate (TEC) 0.8%, micronized talc powder 4%, distilled water 60.2%.

[0074] Add triethyl citrate and talcum powder into water, and use a high-speed emulsifier to homogenize it. Stir before use and add to the Eudragit L30D-55 aqueous dispersion, filter through a 0.25mm sieve to obtain the Eudragi...

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PUM

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Abstract

The invention relates to a micropill for detecting pH in the stomach and its application. Specifically, a kind of intragastric pH detection pellet is provided, the pellet core of the intragastric pH detection pellet contains 13C-labeled NaHCO3, and the coating of the intragastric pH detection pellet is a pH-dependent coating It also provides an intragastric pH detection capsule; and provides the application of the intragastric pH detection pellets and capsules in the preparation of medicines for detecting intragastric pH. The invention has the advantages of: it can accurately determine the pH in the stomach of the subject; the patient has good tolerance and can be tested repeatedly; it is safe and reliable; the operation is simple, and the subject only needs to take the gastric pH detection capsule of the present invention before exhaling The test can be completed; the price is cheap.

Description

technical field [0001] The invention relates to the technical field of medical testing, in particular to a micropill for detecting pH in the stomach and its application. Background technique [0002] Many stomach and esophageal diseases are related to the acidity or alkalinity (pH) level in the stomach. For example, patients with gastric ulcer bleeding need to control the pH in the stomach above 4-5, so that the bleeding point can stop bleeding and the ulcer surface can heal. Another study shows that the pH of gastric juice greater than 4.5-5.5 is conducive to the healing of gastric ulcer disease and reflux esophagitis lesions, so it is the treatment target of clinicians. In view of various reasons, it is often necessary to measure intragastric pH clinically to evaluate the efficacy of drugs or monitor the condition. [0003] Existing intragastric pH measurement methods mainly use a pH detector to detect gastric juice through endoscopy or gastric juice extraction from a ga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02
Inventor 陈颖
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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