New uses of nanometer charcoal suspension injection

Abstract

The invention belongs to the field of medicine, and particularly relates to new uses of a nanometer charcoal suspension injection, particularly to applications of the nanometer charcoal suspension injection in preparation of cancer diagnosis reagents and thermotherapy reagents matched with near-infrared light. According to the present invention, near-infrared light is used to heat the diagnosed tissue and the nanometer charcoal suspension injection can effectively absorb infrared rays to convert into heat, such that the great temperature difference between cancer cells and normal cells is produced; with a thermal imager, the cancer cells and the normal cells are distinguished, and the cancer cell distribution and the metastasis are adjusted, such that the new method for non-invasive diagnosis of cancer cell and malignant tumor draining lymph node cancer draining lymph node trending and distribution by using the nanometer charcoal suspension injection is provided for the public; and near-infrared ray is used to heat the place diagnosed as the cancer cell-containing tissue and location, such that the cancer cell temperature is rapidly increased, the cancer cells are subjected to high temperature killing at the temperature of about 50-56 DEG C, while the normal cells is at the human acceptable level in a short period so as to achieve the purposes of thermotherapy on the malignant tumor primary site and the draining lymph node metastasis.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a new application of nano-carbon suspension injection, in particular to its application in the preparation of medicines for cancer diagnosis reagents and hyperthermia reagents used in conjunction with near infrared light (Near Infrared, NIR). Background technique [0002] Chinese patent application CN 1458185A, patent number: ZL02113731.5, title of invention: a preparation method of a nano-carbon suspension composition, discloses a preparation of a nano-carbon suspension for tracing regional draining lymph nodes of malignant tumors method. The nano-carbon suspension injection is currently a widely used lymphatic tracer for tracing the direction and distribution of malignant tumor drainage lymph nodes. It is clinically used in the diagnosis process by using the characteristics of targeting, that is, to observe the stained cancer cell tissue and Infiltrated lymphoid tissue, thus...

AI Technical Summary

Problems solved by technology

However, during the development of reagents, it was found that these carbon materials are a mixture of a certain particle size range, and it is difficult to control the consistency between batches in the process of refining and surface modification, resulting in differences in product properties between batches, affecting comprehensive evaluation, and hindering late-stage testing

[0005] (2) Particle shape and size are difficult to control

Among the above-mentioned materials, carbon nanotubes have a tubular structure, and the two ends of the preparation process need to be passivated, but usually the treatment may not be complete, and there are still some ends that are like needle points. After administration, these sharp ends The head can easily pierce the blood vessel wall and then enter the nucleus, which has potential genotoxicity

[0006] (3) The targeting is poor and the accuracy is not enough

[0007] (4) Higher cost

Due to the complex preparation process, involving preparation, refining, chemical modification and other steps, the cost is high, which limits its large-scale production and clinical application

[0008] In the above application background, the application of hyperthermia preparations has been limited to the early stage of exploration, and there has not been a safe, stable and controllable reagent that has entered the clinical application stage, which can be safely and effectively used by patients

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