Application of substance for detecting content of serum angiopoetin-like protein 2 in preparation of product for detecting hepatitis and fibrosis degree

An angiopoietin and fibrosis technology, which is used in the application field of substances for detecting serum angiopoietin-like protein 2 content in the preparation of products for detecting the degree of liver inflammation and fibrosis, which can solve interpretation and sampling errors, inappropriate patients, have bleeding problems

Active Publication Date: 2015-11-04
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, liver biopsy is an invasive examination, with errors in interpretation and sampling, and risks of bleeding and bile leakage, so it is not suitable for all patients
However, the existing non-invasive methods are only s

Method used

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  • Application of substance for detecting content of serum angiopoetin-like protein 2 in preparation of product for detecting hepatitis and fibrosis degree
  • Application of substance for detecting content of serum angiopoetin-like protein 2 in preparation of product for detecting hepatitis and fibrosis degree
  • Application of substance for detecting content of serum angiopoetin-like protein 2 in preparation of product for detecting hepatitis and fibrosis degree

Examples

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Embodiment 1

[0055] Example 1, angptl2 can be used to determine treatment decisions for patients with chronic HBV infection

[0056] 1. Research objects: (1) Source of cases: 309 patients with chronic HBV (hepatitis B virus, hepatitis B virus) infection. (2) Inclusion criteria: age 18-65 years old; HBsAg positive history for half a year or more (quantitative detection of HBsAg in serum was performed using Roche kits from the United States (Roche HBsAg II assay)). (3) Exclusion criteria: patients with chronic hepatitis C, AIDS infection, hereditary liver disease, drug liver, non-alcoholic fatty liver and other basic patients; patients with primary liver cancer, liver cirrhosis and pregnant women. All research subjects signed the informed consent form before enrollment.

[0057] 2. angptl2 can be used to determine treatment decisions in patients with chronic HBV infection

[0058] Liver puncture histopathological examination: 309 patients with chronic HBV infection were performed accordi...

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Abstract

The invention discloses an application of a substance for detecting the content of a serum angiopoetin-like protein 2 (angptl2) in preparation of a product for detecting hepatitis and fibrosis degree. Experiments find out that the content of the angptl2 in serum has correlation with the hepatitis degree and fibrosis degree of a chronic hepatitis B virus infected patient, the content of the angptl2 can be used as a noninvasive single indicator for judging the hepatitis degree and fibrosis degree, the substance for detecting the content of the serum angptl2 or a substance for detecting other common clinical indicators of hepatopath can be combined together to prepare the product for detecting the human hepatitis degree and/or fibrosis degree, a product for diagnosing or auxiliarily diagnosing whether patients with hepatopathy need liver biopsy detection or a product for screening or auxiliarily screening the patients with hepatopathy who need or do not need liver biopsy.

Description

technical field [0001] The invention relates to the application of a substance for detecting serum angiopoietin-like protein 2 content in the preparation of products for detecting liver inflammation and fibrosis degree in the field of biomedicine. Background technique [0002] Asia-Pacific and American Association of Liver Diseases recommendations on treatment decision-making guidelines for patients with chronic hepatitis B virus (HBV) infection: ALT ≥ 2ULN, HBV DNA ≥ 20000IU / mL (HBeAg-positive) or HBV DNA ≥ 2000IU / mL (HBeAg-negative) HBV-infected patients need to be given antiviral treatment. For patients in the gray zone who do not meet the above cut-off values, it is necessary to assist in determining the treatment plan based on the pathological results of liver biopsy. Liver puncture pathology shows moderate to severe inflammation or obvious fibrosis requires immediate antiviral treatment. However, liver biopsy is an invasive examination, with interpretation and sampli...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 王贵强邓永琼赵鸿李俊王艳洪源周继远贾伟方雨晴
Owner PEKING UNIV FIRST HOSPITAL
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