A kind of antitumor pharmaceutical composition and its preparation method and application
A composition and anti-tumor technology, applied in the field of biomedicine, can solve the problems of not meeting the technical requirements of clinical disease treatment, etc., and achieve the effect of prolonging the overall survival period, high social benefits, and good stability
Active Publication Date: 2017-11-24
李宏 +1
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Problems solved by technology
[0011] Obviously, glufosfamide has great application prospects in the treatment of tumors, but in view of its severe renal toxicity, although the research and development personnel in the United States, Japan, Germany, India and other countries have experienced many years of creative work, there is currently no product at home and abroad It can be approved for marketing by the relevant national drug regulatory department, but it does not meet the technical requirements for clinical disease treatment
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Embodiment 1
[0037] This embodiment provides an anti-tumor pharmaceutical composition, which contains 100 parts of glufosfamide and 0.01 part of cyclophosphamide in parts by weight.
Embodiment 2
[0039] This embodiment provides an anti-tumor pharmaceutical composition, which contains 70 parts of glufosfamide and 3 parts of cyclophosphamide in parts by weight.
Embodiment 3
[0041] This embodiment provides an anti-tumor pharmaceutical composition, which contains 10 parts of glufosfamide and 2 parts of cyclophosphamide in parts by weight.
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The invention relates to an anti-tumor pharmaceutical composition and its preparation method and application, belonging to the technical field of biomedicine. The anti-tumor pharmaceutical composition is freeze-dried powder injection, containing 10-100 parts of glufosfamide and 0.01-5 parts of cyclophosphamide in parts by weight; its preparation method includes liquid preparation, sterile filtration, filling, Vacuum freeze-drying, nitrogen filling, rubber stopper sealing, capping and other steps. The composition has good stability, high purity, low by-products and little side effects, is used for clinical treatment of pancreatic cancer, is safe and effective, and has higher social benefits.
Description
technical field [0001] The invention relates to an anti-tumor pharmaceutical composition and its preparation method and application, in particular to a glufosfamide composition and its preparation method and application, and belongs to the technical field of biomedicine. Background technique [0002] Pancreatic cancer is a relatively common malignant tumor, accounting for 2% of all malignant tumors. There are two types of cells in the pancreas, endocrine and exocrine. Cancers from endocrine cells are called endocrine cancers, and cancers from exocrine cells are called exocrine cancers. The degree of malignancy of the two varies greatly. Endocrine cancer is relatively rare in clinical practice. This kind of pancreatic cancer is not highly malignant, and the postoperative survival time of patients is longer. Most exocrine carcinomas have a poor prognosis. Clinically, 90-95% of exocrine carcinomas are pancreatic carcinomas derived from ductal cells. This kind of "ductal pancre...
Claims
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IPC IPC(8): A61K31/7024A61K9/19A61P35/00A61P1/18A61K31/675
Inventor 刘新红李宏岳昌林于自勋潘自国陈应林
Owner 李宏
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