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A kind of preparation technology of high-content compound Houttuynia cordata mixture

A compound Houttuynia cordata and preparation technology, which is applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve the problems of low content of active ingredients, poor stability of drugs, and poor clinical curative effect. The effect of less dosage, fine precipitation, and avoiding a large amount of accumulation

Active Publication Date: 2018-05-25
浙江康恩贝中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a preparation process of high-content compound Houttuynia mixture, which solves the technical problems such as low content of medicinal components, poor clinical curative effect, and poor drug stability in the existing compound Houttuynia mixture

Method used

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  • A kind of preparation technology of high-content compound Houttuynia cordata mixture
  • A kind of preparation technology of high-content compound Houttuynia cordata mixture
  • A kind of preparation technology of high-content compound Houttuynia cordata mixture

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Embodiment 1: the preparation of compound Houttuynia cordata mixture A

[0038] Prescription (contains main medicinal materials and excipients):

[0039]

[0040] Preparation:

[0041] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500 g of Houttuynia cordata, add 8 times the volume of 50% ethanol solution to soak for 1 hour, and then perform flash extraction. The flash extraction time is 2 minutes, and the flash extraction speed is 4500 rpm. Filter , the dregs were extracted once more, and the combined filtrate was concentrated to a clear paste with a relative density of 1.08 (60°C);

[0042] (2) Steam distillation: according to the prescription ratio of the above-mentioned compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Radix, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herb residue in step (1), add 11 times the volume of water to carry out Stea...

Embodiment 2

[0046] Embodiment 2: the preparation of compound Houttuynia cordata mixture B

[0047] Prescription (contains main medicinal materials and excipients):

[0048]

[0049]

[0050] Preparation:

[0051] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500 g of Houttuynia cordata, add 5 times the volume of 70% ethanol solution to soak for 0.5 h, and then perform flash extraction. The flash extraction time is 1 min, and the flash extraction speed is 3500 rpm. Filtrate, repeat the extraction of the medicinal residue once more, and concentrate the filtrate to a clear paste with a relative density of 1.10 (80°C);

[0052] (2) Steam distillation: according to the prescription ratio of the above compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Isatidis, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herba residue in step (1), add 8 times the volume of water to carry...

Embodiment 3

[0056] Embodiment 3: the preparation of compound Houttuynia cordata mixture C

[0057] Prescription (contains main medicinal materials and excipients):

[0058]

[0059] Preparation:

[0060] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500g of Houttuynia cordata, add 6 times the volume of 30% ethanol solution to soak for 2 hours, then perform flash extraction, flash extraction time 5min, flash extraction speed 4000rpm, filter , and the dregs were repeatedly extracted twice, and the combined filtrate was concentrated to a clear paste with a relative density of 1.09 (80°C);

[0061] (2) Steam distillation: according to the prescription ratio of the above compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Isatidis, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herba residue in step (1), add 10 times the volume of water to carry out Steam distilled for 1 hour...

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Abstract

The invention discloses a preparation process of high-content compound Houttuynia cordata mixture, which is prepared with Houttuynia cordata, scutellaria baicalensis, Radix Radix Isatidis, forsythia and honeysuckle as main medicinal materials. The medicinal ingredients contained in the mixture and their content are: fishy Grass root 10-25μg / ml, quercitrin 50-100μg / ml, baicalin 1-2mg / ml, forsythin 15-40μg / ml; the preparation steps include: (1) flash extraction; (2) water vapor Distillation; (3) Alcohol precipitation; (4) Water precipitation; (5) Preparation. The preparation process provided by the present invention can not only effectively increase the content of effective ingredients such as houttuyniatin and quercitrin in the compound houttuynia mixture, but also remove polysaccharides, proteins, tanning and other ingredients in medicinal materials, reducing the amount of time spent on sales during storage. The produced precipitation improves the stability and safety of the drug, and can effectively treat sore throat, acute pharyngitis and tonsillitis caused by exogenous wind-heat when used alone.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation process of high-content compound Houttuynia cordata mixture, which is mainly used for treating sore throat, acute pharyngitis and tonsillitis caused by exogenous wind-heat. Background technique [0002] Compound Houttuynia Herba Mixture, as a traditional Chinese medicine, is included in the National Drug Standards. Its prescription composition and preparation method are as follows: [0003] Prescription: Houttuynia cordata 100g Scutellaria baicalensis 25g Radix isatidis 25g Forsythia 10g Honeysuckle 10g Sucrose 60g Honey 200g Sodium benzoate 2g Ethylparaben 0.5g [0004] Made: 1000ml [0005] Preparation method: decoct the above five medicinal materials with water twice, 2 hours each time, combine the decoction liquid, filter, concentrate the filtrate to a clear paste with a relative density of 1.18-1.20 (60°C-80°C), add ethanol to precipitat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61P11/04A61P11/00
Inventor 王建方姚建标印晓红吴健王如伟金汉台陈卿兰文一
Owner 浙江康恩贝中药有限公司
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