Preparation method for Torvosaurus liquid and application of Torvosaurus liquid

A technology of making salt and wine, which is applied in the field of preparation of Manlongye, can solve the problems of large dosage for patients, rough process, affecting application, etc., and achieve the effect of reducing dosage

Active Publication Date: 2015-12-30
云南云龙制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the use of microwave technology in the extraction and preparation of Manlongye, but the use of ethanol reflux and other methods, the process is rou...

Method used

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  • Preparation method for Torvosaurus liquid and application of Torvosaurus liquid
  • Preparation method for Torvosaurus liquid and application of Torvosaurus liquid
  • Preparation method for Torvosaurus liquid and application of Torvosaurus liquid

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1: Take 25g of male silk moth, 25g of Acanthopanax, 17.5g of wine-made dodder, 20g of Epimedium, 10g of salt-made Rehmannia glutinosa, and 10g of salt-made psoralen, grind them, add 2L of 70% ethanol, and put them into microwave extraction Microwave extraction was carried out in the device, the extraction power was 400W, and the extraction was performed twice, 4 minutes each time, the extracts were combined, concentrated, added to the D101 macroporous adsorption resin column, eluted with 50% ethanol, and collected 5 times the column volume eluate , recover ethanol under reduced pressure, concentrate, add 5g of sucrose, 500ml of white wine and an appropriate amount of water to adjust the total amount to 800ml, mix well, and obtain.

Embodiment 2

[0016] Example 2: Take 25g of male silk moth, 25g of Acanthopanax, 17.5g of wine-made dodder, 20g of Epimedium, 10g of salt-made Rehmannia glutinosa, and 10g of salt-made psoralen, grind them, add 2L of 70% ethanol, and put them into microwave extraction Carry out microwave extraction in the device, extraction power 500W, extraction 2 times, 6 minutes each time, combine extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times column volume eluate , recover ethanol under reduced pressure, concentrate, add 5g of sucrose, 500ml of white wine and an appropriate amount of water to adjust the total amount to 800ml, mix well, and obtain.

Embodiment 3

[0017] Example 3: Take 25g of male silk moth, 25g of Acanthopanax, 17.5g of wine-made dodder, 20g of Epimedium, 10g of salt-made Rehmannia glutinosa, and 10g of salt-made psoralen, grind them, add 2L of 70% ethanol, and put them into microwave extraction Microwave extraction was carried out in the device, the extraction power was 600W, the extraction was 2 times, 8 minutes each time, the extracts were combined, concentrated, added to the D101 macroporous adsorption resin column, eluted with 50% ethanol, and 5 times the column volume eluent was collected , recover ethanol under reduced pressure, concentrate, add 5g of sucrose, 500ml of white wine and an appropriate amount of water to adjust the total amount to 800ml, mix well, and obtain.

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PUM

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Abstract

The invention provides a preparation method for Torvosaurus liquid. The Torvosaurus liquid is prepared by taking 25g of male silk moth, 25g of acanthopanax, 17.5g of wine-processed semen cuscutae, 20g of herba epimedii, 10g of salt-processed prepared rehmannia root and 10g of salt-processed fructus psoraleae as raw material medicines; the Torvosaurus liquid is prepared by microwave extraction, so that the Torvosaurus content is greatly increased, and the dose is reduced. The invention also provides the application of the Torvosaurus liquid in preparing drugs for restraining murine melanoma 16B cell proliferation and drugs for treating or preventing dengue virus infection.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Manlongye. Background technique [0002] Manlongye is recorded in the ministerial standard, the prescription is 25g of male silkworm moth, 25g of Acanthopanax, 17.5g of wine-made dodder, 20g of epimedium, 10g of salt-made Rehmannia glutinosa, 10g of salt-made psoralen, and the above six flavors, take male silkworm moth Add an appropriate amount of white wine, soak for 30 days, depressurize the extract to recover ethanol, and make a liquid extract; add 70% ethanol to extract the other five flavors such as Acanthopanax acanthopanax, the first time is 4 hours, and the second time is 2 hours, combined extraction Liquid, filtered, the filtrate recovered ethanol to an appropriate amount, added ethanol to make the alcohol content 70%, stood still for 24 hours, filtered, the precipitate was washed with an appropria...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K36/804A61P35/00A61K35/64
CPCY02A50/30
Inventor 杨建云
Owner 云南云龙制药股份有限公司
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