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Application of Linderolide G in preparing medicine for resisting tubercle bacillus

An anti-tuberculosis and drug technology, applied in the application field of Linderolide G in the preparation of anti-tuberculosis drugs, can solve the problems of non-standard treatment and management of tuberculosis patients and difficulties in tuberculosis prevention and control work

Inactive Publication Date: 2016-01-13
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time, which has caused great difficulties in the prevention and control of tuberculosis

Method used

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  • Application of Linderolide G in preparing medicine for resisting tubercle bacillus
  • Application of Linderolide G in preparing medicine for resisting tubercle bacillus
  • Application of Linderolide G in preparing medicine for resisting tubercle bacillus

Examples

Experimental program
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Effect test

Embodiment 1

[0010] Embodiment 1: Preparation of the compound LinderolideG tablet involved in the present invention:

[0011] Take 5 grams of the compound LinderolideG, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0012] Embodiment 2: the preparation of compound LinderolideG capsules involved in the present invention:

[0013] Take 5 grams of the compound LinderolideG, add 180 grams of starch, mix well, and make 1000 capsules.

experiment example 1

[0014] Experimental Example 1: Determination of the Absolute Concentration of LinderolideG Against Bacillus Calmette-Guerin (BCG) by the Solid Medium Dilution Method

[0015] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0016] LinderolideG is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted LinderolideG is added to 4ml Middlebrook7H11 agar medium according to the required dose (the culture The base has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Li...

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Abstract

The invention discloses application of Linderolide G in preparing a medicine for resisting tubercle bacillus. It discovers that the Linderolide G has a significant activity on inhibiting tubercle bacillus and has a good application prospect; the Linderolide G, which belongs to a totally new skeleton type and has a strong inhibitory activity on the tubercle bacillus, has outstanding substantive features; and meanwhile, the Linderolide G makes a clearly significant progress in the prevention and control of tubercle bacillus infection.

Description

technical field [0001] The present invention relates to the new application of the compound LinderolideG, in particular to the application of LinderolideG in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time has caused great difficulties in the prevention and control of tuberculosis. Therefore, finding new anti-tuberculosis drugs, especially anti-multidrug resistance anti-tuberculosis drugs, is of great significance to protect people's health. [0003] The compound LinderolideG involved in the present invention is a new compound published in 2013 (Q...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61P31/06
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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