Polyethylene material modified by rhodium complexes and preparation method and application thereof

A technology of rhodium complexes and polyethylene, which is applied in the field of polyethylene materials modified by rhodium complexes and its preparation and application, can solve problems such as bacterial invasion, patient infection, and lack of biocompatibility, so as to avoid infection and improve biocompatibility. Compatibility, the effect of excellent anti-bone cancer ability

Active Publication Date: 2016-04-06
东营市大学科技园发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of polyethylene as a medical material often faces problems such as lack of biocompatibility and bacterial invasion, leading to postoperative infection problems in patients

Method used

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  • Polyethylene material modified by rhodium complexes and preparation method and application thereof
  • Polyethylene material modified by rhodium complexes and preparation method and application thereof
  • Polyethylene material modified by rhodium complexes and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0032] A polyethylene material, the surface of the polyethylene material is modified with a rhodium complex.

[0033] The structural formula of the rhodium complex is formula (I);

[0034]

[0035] The chemical name of the rhodium complex is: a chloro-m-thiazolylbenzaldehyde acetal 4-phenyl-3-thiosemicarbazide-pentamethylcyclopentadienyl rhodium (III), and the rhodium complex The molecular formula is: C 27 h 32 OSN 4 Rh, the relative molecular weight of the rhodium complex is: 563.543;

[0036] Physical and chemical properties: It is a red crystal, easily soluble in water and organic solvents, and its H NMR spectrum data is 1 HNMR (CDCl 3 solvent): δ=9.59(br,1H), 9.25(br,1H), 8.28(s,1H), 7.77(s,1H), 7.71(m,3H, J=7.6Hz), 7.62(t,1H ,J=7.6Hz),7.31(t,2H,J=7.9Hz),7.15(d,1H,J=7.2Hz),5.61(d,1H,J=6.0Hz),4.99(d,1H,J =6.0Hz), 4.75(d,1H,J=5.4Hz),4.51(d,1H,J=5.4Hz),3.68(s,3H),2.65(m,1H),2.56(m,1H,J = 6.9Hz), 2.39 (s, 3H), 1.36, 1.25 (2d, 6H, J = 6.7Hz) ppm.

[0037] The prepar...

example 2

[0051] A polyethylene material, the surface of the polyethylene material is modified with a rhodium complex.

[0052] The structural formula of the rhodium complex is formula (I);

[0053]

[0054] The chemical name of the rhodium complex is: a chloro-m-thiazolylbenzaldehyde acetal 4-phenyl-3-thiosemicarbazide-pentamethylcyclopentadienyl rhodium (III), and the rhodium complex The molecular formula is: C 27 h 32 OSN 4 Rh, the relative molecular weight of the rhodium complex is: 563.543.

[0055] The preparation method of described rhodium complex comprises the following steps:

[0056] Step 1. Dissolve 3-(2-thiazolyl)-benzaldehyde in absolute ethanol, add 4-phenyl-3-thiosemicarbazide, stir under reflux at 60°C, and react for 4 to 6 hours to obtain a slightly purple color solution, rotary evaporation to obtain the first concentrated product, adding ethanol and n-hexane, and standing to separate out white crystals to obtain m-thiazolylbenzaldehyde acetal 4-phenyl-3-thiose...

example 3

[0069] A polyethylene material, the surface of the polyethylene material is modified with a rhodium complex.

[0070] The structural formula of the rhodium complex is formula (I);

[0071]

[0072] The chemical name of the rhodium complex is: a chloro-m-thiazolylbenzaldehyde acetal 4-phenyl-3-thiosemicarbazide-pentamethylcyclopentadienyl rhodium (III), and the rhodium complex The molecular formula is: C 27 h 32 OSN 4 Rh, the relative molecular weight of the rhodium complex is: 563.543.

[0073] The preparation method of described rhodium complex comprises the following steps:

[0074] Step 1. Dissolve 3-(2-thiazolyl)-benzaldehyde in absolute ethanol, add 4-phenyl-3-thiosemicarbazide, stir under reflux at 70°C, and react for 6 hours to obtain a slightly purple solution. Rotary evaporation to obtain the first concentrate, adding ethanol and n-hexane, standing to separate out white crystals, to obtain m-thiazolylbenzaldehyde acetal 4-phenyl-3-thiosemicarbazide, its struct...

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PUM

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Abstract

The invention discloses a polyethylene material. The surface of the polyethylene material is modified by rhodium complexes. The structural formula of the rhodium complexes is shown in formula (I) (please see the formula in the specification). The invention further discloses a preparation method and application of the polyethylene material. The surface of the polyethylene material is modified by the rhodium complexes through the recognizing effect of the rhodium complexes on calf thymus deoxyribonucleic acid, and the obtained polyethylene material has high antibacterial and anticancer capacity.

Description

technical field [0001] The invention relates to a polyethylene material modified by a rhodium complex, a preparation method and application thereof. More specifically, the present invention relates to a rhodium complex-modified polyethylene material obtained by using the rhodium complex to recognize calf thymus deoxyribonucleic acid, as well as its preparation method and application. Background technique [0002] With the development of science and technology, medical materials have played an increasingly important role. Polyethylene is widely used in the pharmaceutical industry as artificial blood vessels, catheters and other materials due to its non-toxic, chemical resistance and other advantages. However, the use of polyethylene as a medical material often faces problems such as lack of biocompatibility and bacterial invasion, leading to postoperative infection in patients. Recently, researchers have focused on improving polyethylene's antibacterial and other capabiliti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/54A61L29/04A61L29/16C08J7/12C08L23/06
CPCA61L27/16A61L27/507A61L27/54A61L29/041A61L29/16A61L2300/224A61L2300/404A61L2300/416A61L2400/18C08J7/12C08J2323/06C08L23/06
Inventor 李培源苏炜霍丽妮陈睿
Owner 东营市大学科技园发展有限责任公司
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