Application of calcium-activated chloride channel antagonist

A chloride ion channel and antagonist technology, applied in the field of medicine, can solve problems such as poor curative effect, and achieve the effect of good resistance to denervation and demyelination symptoms

Inactive Publication Date: 2016-04-20
WUHAN WORLDNER UNITED PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no good treatment method, and hormone therapy and n

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  • Application of calcium-activated chloride channel antagonist

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Embodiment Construction

[0011] The present invention will be further described below in conjunction with embodiment.

[0012] Niflumic acid is a well-recognized calcium-activated chloride channel antagonist. It is currently mainly used as a non-steroidal anti-inflammatory analgesic in clinical practice. Its efficacy is superior to other anti-inflammatory analgesics and can be used in elderly patients. It is used for acute and chronic arthritis and non-arthritis, trauma and postoperative inflammation, and can also be used for bronchitis, pneumonia, acute superficial thrombophlebitis, etc.

[0013] This embodiment provides the use of calcium-activated chloride channel antagonists in the preparation of drugs for the treatment of nerve demyelinating diseases.

[0014] The nerve demyelinating diseases include multiple sclerosis, acute infectious polyradiculoneuritis, multifocal leukoencephalitis, subacute sclerosing panencephalitis, central pontine myelin breakdown, progressive subcortical defect Hemorrh...

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Abstract

The invention belongs to the field of medicine and particularly relates to application of a calcium-activated chloride channel antagonist, in particular to application of the calcium-activated chloride channel antagonist in preparing medicine for treating nerve demyelination diseases. According to the application, it is proposed for the first time that the calcium-activated chloride channel antagonist is used for preparing the medicine for treating nerve demyelination diseases, and the diseases such as multiple sclerosis, acute infectious polyradiculoneuritis, multifocal leukoencephalitis, sub-acute sclerosing panencephalitis, pons central type myelin disintegrative disorder, progressive subcortical ischemic encephalopathy, senile dementia and schizophrenia can be safely, efficiently and stably treated.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the use of calcium-activated chloride ion channel antagonists. Background technique [0002] Nerve fibers are divided into unmyelinated nerve fibers and myelinated nerve fibers. Myelinated nerve fibers, such as preganglionic autonomic fibers and larger somatic nerve fibers, have an outer sheath called myelin on their axons. Myelin consists of the cell membrane of myelinating cells. The myelinating cells of the central nervous system are oligodendrocytes, and the myelin sheath of peripheral nerve fibers is composed of Schwann cells. Myelin is composed of lipids and proteins. It can protect the axon and has an insulating effect on nerve impulses, which can accelerate the conduction of nerve impulses. Fibers with a thick myelin sheath conduct impulses faster. When myelin is damaged, conduction velocity slows. Nerve conduction is also affected by temperature, and an increase in body tem...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/44A61P25/00A61P25/28A61P25/18A61P9/10
Inventor 武双婵张倩颖岳源杜思达丁虹
Owner WUHAN WORLDNER UNITED PHARMA
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