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Method for delaying reproduction function decline of female animals

A technology for female animals with functional decline, applied in diseases, drug combinations, medical formulas, etc., can solve problems such as incomplete research, achieve the effects of increasing litter size, convenient addition on demand, and realizing wide-scale use

Active Publication Date: 2016-05-25
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the research on the relationship between melatonin and reproductive function in the prior art is not comprehensive. If a method can be developed to delay the decline of reproductive function in female mice, it will have guiding significance for other species

Method used

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  • Method for delaying reproduction function decline of female animals
  • Method for delaying reproduction function decline of female animals
  • Method for delaying reproduction function decline of female animals

Examples

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Effect test

Embodiment 1

[0039] This example relates to a method for feeding melatonin to female animals to delay the decline of their reproductive function. Specifically, 150 Kunming albino rats aged about 8 weeks were randomly divided into 5 groups, and they began to take melatonin from the age of 8 weeks. The daily doses are 600mg / kg, 60mg / kg, 6mg / kg, 0.6mg / kg and 0mg / kg respectively. At the age of about 21 weeks, they were bred and pregnant, and at the age of 24 weeks, the number of litters of mice in each group was counted.

Embodiment 2

[0041] This embodiment relates to the method for feeding melatonin to animals and then delaying its reproductive function decline. Specifically, 150 Kunming albino rats aged about 8 weeks were randomly divided into 5 groups, and they began to take melatonin from the age of 8 weeks. The doses were 600mg / kg, 60mg / kg, 6mg / kg, 0.6mg / kg and 0mg / kg, respectively. The ovaries and uteri of 24-week-old mice in each group were collected, and the levels of MDA and SOD were determined.

Embodiment 3

[0043] This embodiment relates to the method for feeding melatonin to animals and then delaying its reproductive function decline. Specifically, 150 Kunming albino rats aged about 8 weeks were randomly divided into 5 groups, and they began to take melatonin from the age of 8 weeks. The doses were 600mg / kg, 60mg / kg, 6mg / kg, 0.6mg / kg and 0mg / kg, respectively. Select natural estrous female mice, and cage with male mice, and select female mice that see the tie the next morning. In the evening of the third day, the mice were sacrificed, their oviducts were collected, pronuclei were pulled out with a 1ml syringe, and they were graded: usable eggs and unusable eggs, and the number was recorded. The prokaryotic cells of each group were washed out and cultured, and the cleavage rate and blastocyst rate were counted.

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Abstract

The invention relates to the field of animal husbandry and veterinary and particularly discloses a method for delaying the reproduction function decline of female animals, wherein the animals take in melatonin through oral administration. The delaying of the reproduction function decline of female animals is shown by increasing the litter size of older female animals, the SOD level of ovary, the SOD level of uterus, the number of useful eggs, total egg number, cleavage rate or blastocyst rate or reducing the MDA level of the ovary of older female animals, the MDA level of uterus or the number of useless eggs. In the invention, through a large quantity of objective experiments, different optimal intakes are provided aiming at reproduction function decline of specific different female animals so as to realize the best effect of delaying the reproduction function decline of female animals.

Description

technical field [0001] The invention relates to the field of animal husbandry and veterinary medicine, in particular to a method for delaying the decline of reproductive function of female animals. Background technique [0002] Melatonin (Melatonin, MT) is an indole neuroendocrine hormone secreted by the pineal gland, and its secretion has a clear rhythm of day and night. In 1958, the American dermatologist Lerner first isolated this compound from the pineal gland of beef cattle, and identified its chemical structure as N-acetyl-5-methoxytryptamine. Its molecular formula is C 13 h 16 N 2 o 3 , with a molecular weight of 232.27 and a melting point of 116.65-118°C. Melatonin is a highly lipophilic and partially hydrophilic compound, which is neutral and slightly acidic. Insoluble in water, soluble in acetone, ethanol, ether and other organic solvents, easily destroyed by heat. Because melatonin contains an indole ring, it has the properties of an indole heterocycle. In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61P15/00A61P15/08
CPCA61K31/4045
Inventor 刘国世张鲁姬鹏云汪锋张珍珍王静
Owner CHINA AGRI UNIV
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