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Traditional Chinese medicine composition and preparation thereof

A pharmaceutical preparation and a technology for the composition are applied in the field of traditional Chinese medicine compositions and their preparations for the treatment of chronic congestive heart failure, and can solve the problems of poor curative effect, multiple drug forbidden areas, limited clinical application and the like

Inactive Publication Date: 2016-06-01
FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are still many problems to be solved in western medicine treatment: if the clinical symptoms cannot be completely improved, the quality of life of patients is poor; the side effects of drugs limit the clinical application; there are many forbidden areas for medication; poor

Method used

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  • Traditional Chinese medicine composition and preparation thereof
  • Traditional Chinese medicine composition and preparation thereof
  • Traditional Chinese medicine composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The preparation of embodiment 1 Chinese medicine composition granule of the present invention

[0093] Weigh the raw materials according to the following dosage: Astragalus 45g; Ginseng 10g; Salvia miltiorrhiza 30g; Sanleng 15g; 15g.

[0094] The preparation method is as follows:

[0095] (1) Take the raw materials of the above-mentioned consumption;

[0096] (2) Soak the above-mentioned raw materials with 8 times the volume of water for 1 hour;

[0097] (3) Decocting: after boiling, decoct for 2 hours;

[0098] (4) Filtration: add 6 times the amount of water, decoct for 1 hour, and combine the filtrate to filter;

[0099] (5) Concentration: vacuum decompression, the concentration pressure is -0.06 to -0.08MPa, and the temperature is 90°C;

[0100] (6) Drying and forming: spray drying and granulation, the pressure is -0.06 to -0.08MPa, and the temperature is 180°C. Each pack is 5g, containing 18.1g of crude drug.

[0101] Embodiment 2 The effect of the granule of...

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Abstract

The invention provides a traditional Chinese medicine composition, which comprises the following ingredients (by weight): 25-65 parts of radix astragali, 0-20 parts of ginseng, 10-50 parts of red sage root, 5-25 parts of rhizoma sparganii, 20-40 parts of polygonum aviculare, 5-25 parts of black prepared lateral root of aconite, 5-25 parts of deerhorn glue, 10-50 parts of poria cocos, 5-25 parts of donkey-hide gelatin, 15-45 parts of spine date seed, 0-20 parts of semen arecae prepareta and 5-25 parts of honey-fried licorice root. In clinical application, the traditional Chinese medicine composition can obviously relieve clinical symptoms of patients with chronic congestive heart failure and raise exercise tolerance and living quality. In the long term, left ventricular end-diastolic diameter can be reduced, left ventricular ejection fraction (EF) of heart is raised, blood plasma NT-proBNP level and circulating endothelial cell number can be reduced, and rehospitalization frequency of patients is decreased. The traditional Chinese medicine composition has steady and lasting effects and has no obvious toxic or side effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating chronic congestive heart failure and its preparation. Background technique [0002] Heart failure is the terminal state of various heart diseases and the main cause of death in heart disease patients. In recent years, the incidence of heart failure has been increasing year by year. In the United States, the prevalence of heart failure in adults (>25 years old) is 1.5%-2.0%, and there are about 5 million patients, with an increase of 500,000-700,000 people every year. More than 400,000 people died of heart failure; in Europe, there are about 15 million patients with heart failure, the prevalence rate is 2%-3%, 40% of hospitalized patients with heart failure die within 1 year or need to be hospitalized again; in China, heart failure The incidence rate is 0.9%, that is, there are about 4 million heart failure patients among adults a...

Claims

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Application Information

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IPC IPC(8): A61K36/902A61P9/04A61P29/00A61P9/10A61P9/12A61P9/06A61P9/00A61P11/00A61K35/32A61K35/36
Inventor 马丽红
Owner FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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