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Skin lightening cosmetic compositions and methods

A technology of cosmetic composition and compound, which is applied in the field of up-regulating proteasome protease activity, and can solve problems such as melanin reduction

Active Publication Date: 2016-06-15
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it is believed that upregulation of proteasome protease activity can lead to decreased melanin production in melanocytes

Method used

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  • Skin lightening cosmetic compositions and methods
  • Skin lightening cosmetic compositions and methods
  • Skin lightening cosmetic compositions and methods

Examples

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Embodiment Construction

[0008] Reference in the specification to "one or more embodiments" or the like means that a particular material, feature, structure, and / or characteristic described in connection with the embodiment is included in at least one embodiment, and optionally a plurality of embodiments However, this does not mean that all embodiments include the described materials, features, structures, and / or characteristics. Furthermore, materials, features, structures, and / or characteristics may be combined in any suitable manner in different embodiments, and materials, features, structures, and / or characteristics may be omitted or substituted for those described. Thus, unless otherwise indicated or stated incompatibility, although not explicitly illustrated in combination, embodiments and aspects described herein may include elements or components of other embodiments and / or aspects or may be combined with other embodiments and / or aspects or combination of elements or components of an aspect. ...

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Abstract

A cosmetic composition for topical application to skin is provided. The cosmetic composition includes vitamin B3 compound, a ricinoleate compound and a dermatologically acceptable carrier. The vitamin B3 compound and the ricinoleate beneficially or even synergistically up-regulate proteasomal protease activity as evidenced by a higher observed net luminescence value relative to the calculated net luminescence value in B16 melanoma cells.

Description

technical field [0001] The present disclosure relates to cosmetic compositions and methods for upregulating the activity of proteasome proteases. Background technique [0002] Beauty-conscious consumers are generally concerned with evenness of skin tone and / or the appearance of hyperpigmented spots, such as sun spots (age spots). As such, cosmetic compositions and methods for addressing these consumer concerns are areas of continuing high interest. In melanocytes, the ubiquitin-proteasome system is known to regulate skin pigmentation by degrading tyrosinase or microphthalmia-associated transcription factors. In addition, it is believed that upregulation of proteasome protease activity can lead to decreased melanin production within melanocytes. See eg Hakozaki et al., Aregulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melan synthesis and the appearance off acial hyperpigmented spots, British Journal of Dermatology 2013, 169 (Suppl 2), pp. 39-44. See a...

Claims

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Application Information

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IPC IPC(8): A61Q19/02A61K8/67A61K8/36A61K8/06A61K8/37
CPCA61K8/06A61K8/361A61K8/37A61K8/675A61K2800/592A61Q19/02
Inventor 箱崎智洋L·T·罗琳二世M·C·萨宾诺
Owner THE PROCTER & GAMBLE COMPANY
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