Ion mobility spectrometer and method of using the same

An ion and mass spectrometry technology, applied in the field of ion mobility mass spectrometers, can solve problems such as low resolution, long gating pulses, and reduced peak resolution of mass spectra

Inactive Publication Date: 2016-07-06
RAPISCAN SYST INC (US)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Higher mobility ions will also have higher mass spectral peaks with longer gating pulses, but will result in significantly lower resolving power, thereby reducing the resolution of the mass spectral peaks

Method used

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  • Ion mobility spectrometer and method of using the same
  • Ion mobility spectrometer and method of using the same

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Embodiment Construction

[0013] Embodiments described herein provide a cost-effective system and method for improving the detection of material of interest from a subject or person. The systems and methods described herein use two different short pulse widths to inject ions from the ionization region into the drift region during de-energization of the ion gate. The first (ie, narrower) pulse width facilitates deactivating the ion gate for a shorter period of time, thereby enhancing detection of high mobility ions by generating a first mass spectral trace comprising multiple resolved high mobility ion peaks. Likewise, the resolution of mass spectrometric traces of high mobility analytes is enhanced. The same first mass spectral trace includes a low mobility ion peak having a first amplitude. The second (i.e., wider) pulse width facilitates de-energizing the ion gate for longer periods of time, thereby enhancing the detection of low mobility ions by generating a mass spectral trace that includes low mo...

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Abstract

The invention relates to an ion mobility spectrometer and a method of using the same. A method of detecting constituents in a sample includes generating a plurality of ions in an ionization region. The method also includes preventing the plurality of ions in the ionization region from flowing into a drift region through inducing a first voltage in a device positioned between the two regions. The method further includes injecting at least a portion of the ions from the ionization region into the drift region. The method also includes regulating the voltage in the device to a second voltage for a first predetermined temporal period, the second voltage less than the first voltage. The method further includes regulating the voltage in the device to the first voltage. The method also includes regulating the voltage in the device to the second voltage for a second predetermined temporal period, the second predetermined temporal period different from the first predetermined temporal period.

Description

Background technique [0001] Embodiments described herein relate generally to ion mobility mass spectrometers (IMS), and more particularly, to IMS detection systems for enhanced detection of materials of interest through enhanced resolution of high and low mobility ions . [0002] At least some known mass spectrometry detection devices include time-of-flight (TOF) ion mobility mass spectrometer (IMS) detection systems. Such TOF-IMS detection systems are used to detect trace portions of materials of interest, such as residues in the presence of interfering substances in collected samples. In at least some known TOF-IMS detection systems, ions are generated in the ionization region to increase the population of ions therein. Ion gates (sometimes referred to as ion shutters) comprising a conductive grid of interlaced wires, such as a Bradbury-Nielson gate, are held at a "cutoff" condition configured to prevent the transfer of ionic current from the ionization region . Excitati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62H01J49/06
CPCG01N27/622H01J49/06
Inventor L.K.格德克
Owner RAPISCAN SYST INC (US)
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