Application of fumarate compound to preparation of adjusting medicine for macrophage subpopulation

Abstract

The invention provides application of a fumarate compound to the preparation of an adjusting medicine for a macrophage subpopulation. Discovered experimentally, the fumarate compound can be used for decreasing the level of a pro-inflammatory M1-type macrophage of a mammal, and meanwhile, can be used for raising the level of an anti-inflammatory M2-type macrophage, and such a change is clear to realize by promoting the differentiation of the M1-type macrophage to the M2-type macrophage. On this basis, the fumarate compound is discovered to be capable of increasing the expression quantities of a nuclear transcription factor 2 (Nrf2) of an anti-oxidation transcription factor and a target gene heme oxygenase 1 (HO-1) thereof, so as to promote the differentiation of the M1-type macrophage to the M2-type macrophage, and therefore, the mechanism of the action of the fumarate compound in the adjustment of the macrophage subpopulation is clear. Based on the above newly discovered new properties, the new purpose for preparing the adjusting medicine for the macrophage subpopulation by utilizing the fumarate compound is determined by the application of the fumarate compound to the preparation of the adjusting medicine for the macrophage subpopulation, so that a new treatment approach is provided for multiple diseases which use the maladjustment of the macrophage subpopulation as an effect.

Description

technical field [0001] The invention relates to the field of medical technology, and further relates to the new medical application of substances, in particular to the application of fumaric acid ester compounds for preparing macrophage subgroup regulating drugs. Background technique [0002] Fumaric acid, also known as fumaric acid or fumaric acid, is an unsaturated dibasic acid with a simple structure. The products after esterification of any carboxyl group are called fumaric acid ester compounds. Due to the similar structure, the pharmacological properties of fumaric acid ester compounds have certain commonality, especially their low-valent alkyl esters, which are effective in antibacterial, antibacterial, and antibacterial properties. It is generally active in the treatment of inflammation and psoriasis. In the prior art, the fumarate compounds used as medicine mainly include dimethyl fumarate, ethyl hydrogen fumarate, monomethyl fumarate, monoethyl fumarate, etc., and ...

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at addressing the technical defects of the prior art, and provides the application of fumarate compounds for the preparation of macrophage subpopulation-regulating drugs, so as to solve the technical problem that the scope of use of fumarate compounds is relatively limited in the prior art

[0007] Another technical problem to be solved by the present invention is that the available drugs for the regulation of macrophage subsets in the prior art are limited

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