Application of pd0325901 in the preparation of medicines for treating Parkinson's

A drug and neuron technology, applied in the field of medicine, can solve the problems that can not be treated fundamentally, can not delay the degeneration of dopaminergic neurons, etc., and achieve the effect of delaying degenerative death and good curative effect

Active Publication Date: 2018-10-30
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But none of them can delay the degeneration of dopaminergic neurons, so they cannot fundamentally play a therapeutic role

Method used

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  • Application of pd0325901 in the preparation of medicines for treating Parkinson's
  • Application of pd0325901 in the preparation of medicines for treating Parkinson's

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Experimental program
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Embodiment Construction

[0010] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0011] The chemical formula of PD0325901 (N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide) is: C 16 h 14 f 3 IN 2 o 4 , the structural formula is:

[0012] , is a MEK inhibitor.

[0013] The present invention provides an application of PD0325901 in the preparation of a drug for treating Parkinson's disease, specifically preparing PD0325901 alone or in combination with other active ingredients or auxiliary materials to prepare a drug for delaying the degeneration of dopaminergic neurons.

[0014] Taking 300 medflies as experimental objects, they were randomly divided into 4 experimental groups and 1 normal control group (Ctrl), 60 in each group, and each group was divided into exp...

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Abstract

The invention belongs to the technical field of medicine, discloses an application of PD0325901 in preparation of a PD (Parkinson's disease) treatment drug and particularly provides an application of the PD0325901 in preparation of a drug for delaying dopaminergic neuron degeneration. A product can effectively delay degenerative death of dopaminergic neurons, and the PD is treated fundamentally; the treatment effect of the drug can be realized through oral administration instead of injection, and the drug has a better curative effect on PD caused by various reasons and has great significance on treatment and healing of PD.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of PD0325901 in the preparation of medicines for treating Parkinson's disease. Background technique [0002] Parkinson's Disease (PD), also known as "parkinson's paralysis", is a common degenerative disease of the central nervous system, mainly affecting middle-aged and elderly people. trend. The main symptoms of patients with Parkinson's disease are slow movement, uncontrollable tremors in hands, feet or other parts of the body, body stiffness, balance disturbance, so that they cannot take care of themselves. According to statistics, the prevalence of Parkinson's among people over 60 years old in my country is about 1.7%, with a total of more than 1 million patients, and at least 100,000 new cases are added every year. The degeneration and death of dopamine (DA) neurons in the substantia nigra of the midbrain, and the significant reduction of DA co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/166A61P25/16
CPCA61K31/166
Inventor 杨宇丰张西孙玲陈文锋倪世伟
Owner FUZHOU UNIV
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