Application of trametinib in preparation of drug for treating Parkinson's disease
A trametinib and drug technology, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of not being able to delay the degeneration of dopaminergic neurons, not being able to fundamentally treat them, and the like. The effect of delaying degenerative death and good curative effect
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[0010] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.
[0011] Trametinib (N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6, The chemical formula of 7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide is: C 26 h 23 FIN 5 o 4 , the structural formula is: , is a MEK inhibitor.
[0012] The invention provides an application of trametinib (Trametinib) in the preparation of drugs for treating Parkinson's disease, specifically preparing trametinib alone or in combination with other active ingredients or auxiliary materials to prepare drugs for delaying degeneration of dopaminergic neurons.
[0013] Taking 300 medflies as experimental objects, they were randomly divided into 4 experimental groups and 1 normal control group (Ctrl), 60 i...
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