Application of trametinib in preparation of drug for treating Parkinson's disease

A trametinib and drug technology, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of not being able to delay the degeneration of dopaminergic neurons, not being able to fundamentally treat them, and the like. The effect of delaying degenerative death and good curative effect

Active Publication Date: 2016-08-03
FUZHOU UNIV
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Problems solved by technology

But none of them can delay the degeneration of dopaminergic neurons, so they cannot fundamentally play a therapeutic role

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  • Application of trametinib in preparation of drug for treating Parkinson's disease
  • Application of trametinib in preparation of drug for treating Parkinson's disease

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Embodiment Construction

[0010] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0011] Trametinib (N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6, The chemical formula of 7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide is: C 26 h 23 FIN 5 o 4 , the structural formula is: , is a MEK inhibitor.

[0012] The invention provides an application of trametinib (Trametinib) in the preparation of drugs for treating Parkinson's disease, specifically preparing trametinib alone or in combination with other active ingredients or auxiliary materials to prepare drugs for delaying degeneration of dopaminergic neurons.

[0013] Taking 300 medflies as experimental objects, they were randomly divided into 4 experimental groups and 1 normal control group (Ctrl), 60 i...

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Abstract

The invention belongs to the technical field of medicine, and discloses application of trametinib in preparation of a drug for treating Parkinson's disease, wherein trametinib is used for preparing the drug to delay the degeneration of dopaminergic neuron. The obtained product can effectively delay the degenerative death of dopaminergic neuron, to treat Parkinson's disease fundamentally; the drug can be taken orally without injection to achieve the treatment effect, has excellent curative effect for Parkinson's disease caused by a variety of reasons, and has important significance for the treatment and curing of Parkinson's disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Trametinib in the preparation of medicines for treating Parkinson's disease. Background technique [0002] Parkinson's disease (Parkinson's Disease, PD), also known as "parkinsonism", is a common degenerative disease of the central nervous system, mainly affecting middle-aged and elderly people. the trend of. The main symptoms of patients with Parkinson's disease are slow movement, uncontrollable tremors in hands, feet or other parts of the body, body stiffness, balance disturbance, so that they cannot take care of themselves. According to statistics, the prevalence of Parkinson's among people over 60 years old in my country is about 1.7%, with a total of more than 1 million patients, and at least 100,000 new cases are added every year. The degeneration and death of dopamine (DA) neurons in the substantia nigra of the midbrain, and the significan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P25/16
CPCA61K31/519
Inventor 杨宇丰张西孙玲陈文锋倪世伟
Owner FUZHOU UNIV
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