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Use of a pharmaceutical composition containing sargrelate for treating or preventing fatty liver, liver fibrosis and/or liver damage

A kind of technology of liver fibrosis and composition, applied in the field of medicine

Active Publication Date: 2019-04-30
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there are no reports on the use of serotonin 2 receptor antagonist sarcogrelate and / or serotonin synthesis inhibitors for the treatment or prevention of fatty liver, liver fibrosis, and liver damage

Method used

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  • Use of a pharmaceutical composition containing sargrelate for treating or preventing fatty liver, liver fibrosis and/or liver damage
  • Use of a pharmaceutical composition containing sargrelate for treating or preventing fatty liver, liver fibrosis and/or liver damage
  • Use of a pharmaceutical composition containing sargrelate for treating or preventing fatty liver, liver fibrosis and/or liver damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] 1 part by weight of sagrester, 5 parts by weight of p-chlorophenylalanine, and dextrin and other commonly used adjuvants for granules are prepared into granules by conventional technology.

Embodiment 2

[0117] 1 part by weight of sagrester, 2 parts by weight of p-chlorophenylalanine, and microcrystalline cellulose and other commonly used auxiliary materials for tablets are compressed into tablets.

Embodiment 3

[0119] 2 parts by weight of sagrellate, 1 part by weight of p-chlorophenylalanine, and dextrin and other commonly used adjuvants for granules are used to make granules by conventional technology, and then poured into hard capsule skins to make capsules.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and discloses application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and / or liver injury. As proved from experiments, the application has the advantages that the fatty livers due to high fat and high cholesterol can be obviously reversed by the aid of the medicine compositions, and the liver fibrosis and the liver injury due to combination effects of the high fat, the high cholesterol and streptozotocin irritation can be obviously reversed.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of a pharmaceutical composition containing sagrelor for treating or preventing fatty liver, liver fibrosis and / or liver damage, in particular to serotonin 2 receptor antagonist sagrelate and The compound pharmaceutical composition of 5-hydroxytryptamine synthesis inhibitor combination is used for treating or preventing fatty liver, liver fibrosis and / or liver damage. Background technique [0002] Fatty liver, the direct manifestation is that the liver produces obvious lipid deposition, and the content of triglyceride (TG) in the liver tissue can be detected to be significantly increased, and the observation of tissue sections shows that there are obvious lipid droplets in the liver cells. Further lesions of the liver can develop into liver fibrosis and liver damage. Liver fibrosis can be determined by observing the formation of liver fibrous tissue and detecting the content of hydr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/225A61P1/16A61P3/06A61K31/198A61K31/165
CPCA61K31/165A61K31/198A61K31/225A61K45/06A61K2300/00
Inventor 傅继华
Owner CHINA PHARM UNIV
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