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Composite type biological cannula and preparation method and application thereof

A composite, biological technology, applied in tissue regeneration, microcapsules, pharmaceutical formulations, etc., can solve the problems of undisclosed thickness, volume, use performance and unsatisfactory effects of nerve growth substances, achieve multi-nerve regeneration protection space length, improve Repair effect, foreign body sensation reduction effect

Inactive Publication Date: 2016-12-21
BEIJING HUIFUKANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the Chinese patent document CN 103371875 A discloses a composite biological sleeve and its preparation method and application. This prior art can solve the problem of regenerated nerve axons effectively passing through nerve defects to a certain extent, and is convenient to prepare and store. However, since it only discloses the inner diameter and thickness of the chitin part of the biological conduit in the biological casing, it does not disclose the thickness of the nerve growth-promoting substance and the volume it occupies, but the thickness of the nerve growth substance and the volume it occupies are different. It can lead to huge differences in its performance, and the disclosed composite biological sleeve is not very effective in repairing peripheral nerve defects in animals with small gap sockets

Method used

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  • Composite type biological cannula and preparation method and application thereof
  • Composite type biological cannula and preparation method and application thereof
  • Composite type biological cannula and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Example 1: Preparation of composite biological sleeve

[0047] 1. Preparation of Hollow Biological Catheters

[0048] Commercially available chitosan with a degree of deacetylation of 82% and a weight average molecular weight of 377,000 (purchased from Shanghai Jiahe Biotechnology Co., Ltd.) was dissolved in 2% (weight ratio) at a concentration of 4% (W / W, weight ratio) In dilute acetic acid aqueous solution, a high viscosity solution was obtained. Vacuum degassing for 12 hours to obtain a non-foaming spinning stock solution. The spinning stock solution is extruded from the kettle with an air pressure of 0.6MPa (MPa), metered by a spinning metering pump, and extruded from the cortex of the hollow spinneret hole. At the same time, the air pressure of 0.2MPa A 5% NaOH (W / W) aqueous solution (as coagulant) was extruded from the core of the hollow spinneret hole. After the spinning dope is extruded, it directly enters a 5% NaOH (W / W) aqueous solution coagulation bath, an...

Embodiment 2-7

[0070] The preparation method of the composite biological sleeves of Examples 2-7 is the same as that of Example 1, and the specific result parameters of the composite biological sleeves prepared in each embodiment are shown in Table 1.

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Abstract

The invention provides a composite type biological cannula and a preparation method and application thereof. The composite type biological cannula includes a hollow biological catheter and a sustained release micro-capsule layer which is arranged on the inner wall of the hollow biological catheter; the inner diameter of the biological catheter is 0.8 mm-9 mm, and the wall thickness of the biological catheter is 0.1-2.5 mm; and the thickness of the sustained release micro-capsule layer is 0.05-0.5 mm. The composite type biological cannula is suitable for peripheral nerve interstitium tubulization suture, the sustained release micro-capsule layer on the inner wall of the cannula can sustainably provide nerve growth substances, and the restoration effect of damaged peripheral nerves can be improved.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to a composite biological sleeve and its preparation method and application. Background technique [0002] The conventional treatment method for peripheral nerve detachment injury in clinic is epineurium suture or perineurium suture. Cajal et al. proved that nerve fibers at the proximal stump selectively grow into the distal stump of the nerve, but not into other tissues. This is the tendency of peripheral nerve regeneration (also known as the selective regeneration theory). [0003] Based on the above theory, someone proposed a new method of repairing peripheral nerves: small gap socket suture technique. That is, the severed proximal and distal peripheral nerves are sleeved and sutured with tubular materials. When the sleeves are sutured, a relatively closed nerve regeneration chamber is formed between the two nerve stumps, which is conducive to the function of endogeno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/11A61L27/54A61L27/58A61B17/00
CPCA61B17/1128A61B2017/00893A61L27/54A61L27/58A61L2300/414A61L2300/622A61L2430/32
Inventor 费兴波张海群
Owner BEIJING HUIFUKANG MEDICAL TECH
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