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Anti-inflammatory effective part of leaf of Santalum album L. and preparation method and application of anti-inflammatory effective part of leaf of Santalum album L.

A technology of effective parts and sandalwood leaves, which is applied in the field of medicine, can solve the problems of extraction of effective parts of sandalwood anti-inflammatory, and achieve good therapeutic effects, clear ingredients, and good industrial development prospects

Inactive Publication Date: 2017-01-04
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is reported that sandalwood has anti-inflammatory effect, but there is no research to extract the anti-inflammatory effective part of sandalwood and confirm the efficacy

Method used

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  • Anti-inflammatory effective part of leaf of Santalum album L. and preparation method and application of anti-inflammatory effective part of leaf of Santalum album L.
  • Anti-inflammatory effective part of leaf of Santalum album L. and preparation method and application of anti-inflammatory effective part of leaf of Santalum album L.
  • Anti-inflammatory effective part of leaf of Santalum album L. and preparation method and application of anti-inflammatory effective part of leaf of Santalum album L.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Dry 1kg of sandalwood leaves at 60°C, crush them to pieces, add 8L of 90% ethanol, soak for 12 hours, heat and reflux once, 1 hour each time, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and the recovered liquid passes through AB- 8 macroporous adsorption resin, eluting with 50% ethanol, collecting the eluate to recover ethanol under reduced pressure, beating and dispersing the extract with water, then extracting twice with ethyl acetate, recovering the solvent from the ethyl acetate solution to 20% of the original volume, 4 Place it at ℃ for 12 hours, filter to obtain a precipitate, wash the precipitate twice with 95% ethanol, and detect it with a liquid chromatography ultraviolet detector 268nm area normalization method, vitexin, isovitexin and orientin account for The weight content of effective parts is 97.3%, see attached figure 1 .

Embodiment 2

[0055]Dry 1kg of sandalwood leaves at 60°C, crush them to pieces, add 8L of 90% methanol, soak for 8 hours, heat and reflux twice, 1 hour each time, filter, and recover ethanol from the filtrate until it has no alcohol smell, and the recovered solution passes through D101 large Pore ​​adsorption resin, eluting with 50% ethanol, collecting the eluate to recover methanol under reduced pressure, beating and dispersing the extract with water, then extracting with ethyl acetate for 3 times, recovering the solvent from ethyl acetate to 40% of the original volume, and placing it at 10°C After 12 hours, the precipitate was obtained by filtration, and the precipitate was washed twice with 95% methanol to obtain it. It was detected by the 268nm area normalization method with a liquid chromatography ultraviolet detector, and vitexin, isovitexin and orientin accounted for the effective parts The weight content is 95.6%.

Embodiment 3

[0057] Dry 1kg of sandalwood leaves at 50°C, crush them to pieces, add 8L of 30% ethanol, soak for 4 hours, heat and reflux 3 times, 1 hour each time, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and the recovered solution is passed through D101 large Pore ​​adsorption resin, eluted with 70% ethanol, collected eluent and recovered ethanol under reduced pressure, the extract was beaten and dispersed with water, extracted 4 times with a mixture of n-butanol and ethyl acetate (1:1), and the organic solvent was recovered to the original 60% of the volume, placed at 0°C for 12 hours, filtered to obtain the precipitate, washed twice with ethyl acetate, and detected by liquid chromatography with an ultraviolet detector 268nm area normalization method, vitexin and isovitexin Glycosides and orientin account for more than 95.9% of the weight content of the effective parts.

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Abstract

The invention relates to an anti-inflammatory effective part of a leaf of Santalum album L.. The anti-inflammatory effective part comprises vitexin, isovitexin and orientin, and the content of the vitexin, the isovitexin and the orientin in the effective part is not less than 80%. The invention further provides a preparation method and application of the anti-inflammatory effective part of the leaf of Santalum album L.. The anti-inflammatory effective part of the leaf of Santalum album L. is clear in chemical components and the content of the known components exceeds 80%; systematic anti-inflammatory experiments show that the effective part is effective in treatment of acute inflammation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to anti-inflammatory effective parts of sandalwood leaves, a preparation method and application thereof. Background technique [0002] sandalwood( Santalum album L.) for the Sandalaceae ( Santalaceae) Sandalwood ( Santalum) Plants are widely planted in Guangdong Province, and wood has high application value and is known as "green gold". The formation of volatile oil in the sandalwood heartwood takes more than 10 years, and can only be harvested after more than 20 years. The sandalwood planting industry has a large investment and a long cycle. Sandalwood is an evergreen broad-leaved tree species with a large leaf output. Chemical constituents studies have shown that sandalwood leaves contain a variety of flavonoids, which have not been effectively utilized at present. [0003] Inflammation is a common basic pathological process and a defense response of the body t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00A61K31/7048
CPCA61K36/185A61K31/7048A61K2236/333A61K2236/53A61K2236/55
Inventor 闫冲刘红菊李宝红潘文嘉
Owner GUANGDONG MEDICAL UNIV
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