Benzophenone derivatives as tyrosinase activators and their applications

Abstract

The invention belongs to the technical field of cosmetics, medicines and food chemistry, and discloses benzophenone derivatives serving as tyrosinase activating agents and applications thereof. The benzophenone derivatives serve as the tyrosinase activating agents and are one or more than one of 2-hydroxybenzophenone, 3-hydroxybenzophenone, 4-hydroxybenzophenone, 4-methoxybenzophenone, 4-aminobenzophenone, 3-aminobenzophenone, 4, 4'-dihydroxy benaophenonel, 2, 4, 4'-trihydroxybenzophenone or 3-methoxyl-4, 4'-dihydroxy benaophenonel. The compounds disclosed by the invention have intense tyrosinase activation activity and obvious application prospect in medicines (such as treatment of leucoderma) and cosmetics (such as hair-blacking liquid shampoo).

Description

technical field [0001] The invention relates to the fields of cosmetics, medicines and food chemistry, in particular to a benzophenone derivative used as a tyrosinase activator and its application in cosmetics and medicines. Background technique [0002] Tyrosinase is a multifunctional enzyme containing two copper atoms, which widely exists in microorganisms, animals, plants and the human body. This enzyme utilizes molecular oxygen to catalyze the oxidation of monophenols to diphenols (monophenolase activity) followed by the catalytic oxidation of diphenols to the corresponding quinones. Quinone undergoes a series of enzyme-catalyzed or non-enzyme-catalyzed processes to obtain mixed melanin. [0003] Tyrosinase is related to many biological processes, such as human aging and human pigmentation diseases. Recent studies have shown that the reduction of tyrosinase activity can cause people to suffer from some hypopigmentation diseases, such as: less whiteheads, vitiligo, etc....

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Problems solved by technology

) foreign research on tyrosinase activators is rare

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