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Aryl compounds containing phenolic hydroxyl groups as tyrosinase activators and their applications

A technology of tyrosinase and compounds, which is applied in the fields of pharmaceuticals, food chemistry, and cosmetics, can solve the problems of rare research on tyrosinase activators, and achieve the goal of promoting the production of melanin, improving the activation rate, and improving related diseases Effect

Active Publication Date: 2019-04-23
GUANGDONG IND TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

) foreign research on tyrosinase activators is rare

Method used

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  • Aryl compounds containing phenolic hydroxyl groups as tyrosinase activators and their applications
  • Aryl compounds containing phenolic hydroxyl groups as tyrosinase activators and their applications
  • Aryl compounds containing phenolic hydroxyl groups as tyrosinase activators and their applications

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Embodiment

[0018] Example: Use of aryl compounds containing phenolic hydroxyl groups as tyrosinase activators:

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Abstract

The invention belongs to the technical field of cosmetics, medicine and food chemistry and discloses a phenolic hydroxyl-containing aryl compound acting as tyrosinase activator and application thereof. The phenolic hydroxyl-containing aryl compound is used as tyrosinase activator, and is from more than one of 1,5-dihydroxynaphthalene and 2,2'-diphenol. The compound related herein has strong tyrosinase activating activity, and has significant application prospect in medicine (such as for treating vitiligo) and cosmetics (such as hair-blacking shampoo).

Description

technical field [0001] The invention relates to the fields of cosmetics, medicines and food chemistry, in particular to an aryl compound containing phenolic hydroxyl as a tyrosinase activator and its application in cosmetics and medicines. Background technique [0002] Tyrosinase is a multifunctional enzyme containing two copper atoms, which widely exists in microorganisms, animals, plants and the human body. This enzyme utilizes molecular oxygen to catalyze the oxidation of monophenols to diphenols (monophenolase activity) followed by the catalytic oxidation of diphenols to the corresponding quinones. Quinone undergoes a series of enzyme-catalyzed or non-enzyme-catalyzed processes to obtain mixed melanin. [0003] Tyrosinase is related to many biological processes, such as human aging and human pigmentation diseases. Recent studies have shown that the reduction of tyrosinase activity can cause people to suffer from some hypopigmentation diseases, such as: less whiteheads,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K8/34A61Q5/02A61Q5/10A61P17/00
CPCA61K8/347A61Q5/02A61Q5/10
Inventor 游遨黎彧劳思敏冯安生马林张泽敏邱文达
Owner GUANGDONG IND TECHN COLLEGE
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