Simvastatin tablets capable of lowering blood lipid and preparation method of simvastatin tablets

A technology for simvastatin and blood lipid lowering, which is applied to chemical instruments and methods, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Simple preparation process and good use stability

Inactive Publication Date: 2017-05-10
滁州先奇工业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing simvastatin tablets all use dry compression technology or adopt methods such as inclusion to increase the stability of the preparation, and the dissolution is unstable. Clinically, patients often have some side effects when taking it.

Method used

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  • Simvastatin tablets capable of lowering blood lipid and preparation method of simvastatin tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 10 g of simvastatin, 25 g of ethyl cellulose, 35 g of corn starch, 20 g of D-mannitol, 15 g of guar gum, 15 g of sodium starch glycolate, and 2 g of magnesium stearate.

[0017] Preparation process: Put the simvastatin raw material in a pulverizing equipment to pulverize; mix the pulverized simvastatin raw material and the above-mentioned excipients uniformly in a particle mixer according to the amount, granulate according to a conventional method, compress into tablets, and pack to obtain a finished product.

[0018] Particle mixers above, see figure 1 , including a base 1, a mixing cylinder 2 arranged on the base 1, a stirring motor 3 is arranged in the base 1, the main shaft of the stirring motor 3 is in contact with the center of the bottom wall of the mixing cylinder 2 Connected, the bottom wall in the mixing cylinder 2 is provided with a stirring pole 4, and at least two cavities 5 are evenly arranged vertically in the side wall of the mixing cylinder 2, and...

Embodiment 2

[0022] Weigh 5 g of simvastatin, 30 g of ethyl cellulose, 30 g of corn starch, 30 g of D-mannitol, 5 g of guar gum, 20 g of sodium starch glycolate, and 0.5 g of magnesium stearate.

[0023] The preparation process is the same as above.

Embodiment 3

[0025] Weigh 15 g of simvastatin, 20 g of ethyl cellulose, 40 g of corn starch, 10 g of D-mannitol, 25 g of guar gum, 5 g of sodium starch glycolate, and 3.0 g of magnesium stearate.

[0026] The preparation process is the same as above.

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PUM

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Abstract

The invention relates to simvastatin tablets capable of lowering blood lipid, and belongs to the technical field of western medicine preparations. The simvastatin tablets are prepared from the following components: 5 to 15 parts of simvastatin, 20 to 40 parts of ethyl cellulose, 30 to 50 parts of cereal starch and the like; the components are mixed by adopting a specific grain stirrer. The tablets provided by the invention are stably and slowly released.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a simvastatin tablet for lowering blood fat. Background technique [0002] Simvastatin is a blood lipid-lowering drug of the statin class, which is used to control the content of cholesterol in the blood and prevent cardiovascular diseases. Simvastatin is a synthetic derivative of the fermentation product of Aspergillus terreus. Existing simvastatin tablets all adopt dry compression technology or adopt methods such as inclusion to increase the stability of the preparation, and the dissolution is unstable, and some side effects are often produced when patients take it clinically. Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the present invention provides a simvastatin tablet through a large number of tests on auxiliary material screening, process optimization and equipment improvement. The tablet is sustained-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K47/12A61K31/366A61P3/06B01F7/16
CPCA61K9/2013A61K9/2018A61K9/205A61K9/2054A61K9/2059A61K31/366B01F27/191B01F27/85
Inventor 孙本如
Owner 滁州先奇工业科技有限公司
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